INT25607

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2011
Negated 2
Speculated 5
Reported most in Body
Documents 82
Total Number 88
Disease Relevance 64.40
Pain Relevance 23.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 2
brain 2
endothelial cells 2
synovial fluid 1
chondrocyte 1
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1928 100.00 Very High Very High Very High
cytokine 1401 100.00 Very High Very High Very High
rheumatoid arthritis 867 100.00 Very High Very High Very High
medulla 61 100.00 Very High Very High Very High
Inflammatory response 224 99.98 Very High Very High Very High
agonist 76 99.96 Very High Very High Very High
Central nervous system 546 99.92 Very High Very High Very High
Hippocampus 97 99.84 Very High Very High Very High
antagonist 170 99.60 Very High Very High Very High
metalloproteinase 200 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2130 100.00 Very High Very High Very High
Rheumatoid Arthritis 882 100.00 Very High Very High Very High
Targeted Disruption 321 100.00 Very High Very High Very High
Diabetes Mellitus 120 99.92 Very High Very High Very High
Sprains And Strains 34 99.80 Very High Very High Very High
Hypertrophy 24 99.72 Very High Very High Very High
Crystal Associated Disease 205 99.66 Very High Very High Very High
Plasmodium Infection 119 99.60 Very High Very High Very High
Stress 223 99.56 Very High Very High Very High
Cancer 159 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
signaling, the IL1 type 2 receptor is up-regulated, which is a decoy receptor that binds IL1?
IL1 Binding (binds) of
1) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.81 Pain Relevance 0.54
However, recent meta-analysis has not supported a clear association between IL-1 genetic loci and AD when the data is examined as a whole [122].
IL-1 Neg (not) Spec (clear) Binding (association) of associated with alzheimer's dementia
2) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.38 Pain Relevance 0.08
-inhibitor (0,1 mM) before incubation with IL-1?
IL-1 Binding (incubation) of
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952629 Disease Relevance 0 Pain Relevance 0
In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?
IL1 Binding (immunity) of
4) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.42 Pain Relevance 0.18
The probe used in our study to quantify radical formation has a low affinity for both NO and superoxide compared to peroxynitrite, and since peroxynitrite effectively oxidizes proteins, lipids and DNA, it is likely that IL-1?
IL-1 Spec (likely) Binding (likely) of
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952629 Disease Relevance 0.47 Pain Relevance 0
Beta-endorphin by itself did not induce IL-1 generation.
IL-1 Neg (not) Binding (generation) of
6) Confidence 0.33 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.20
IL-1 is both expressed by and targeted to many different cell types within the CNS.
IL-1 Binding (targeted) of associated with central nervous system
7) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 2.08 Pain Relevance 0.22
Neutrophils are rapidly recruited following CNS injury, present at the time of neuronal death, and can trigger tissue damage through generation of toxic free radicals, proteolytic enzymes and pro-inflammatory cytokines such as IL-1?
IL-1 Binding (generation) of in neuronal associated with inflammation, injury, central nervous system, death and cytokine
8) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.00 Pain Relevance 0.33
IL-1 has been associated with neuroprotective mechanisms in rodent primary neuron cultures which may be mediated in part by production of survival signals such as nerve growth factor (NGF) [80-82].
IL-1 Binding (associated) of in nerve associated with nerve growth factor
9) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.83 Pain Relevance 0.13
Conversely, ischemic damage is greatly reduced by knockout of IL-1?
IL-1 Binding (knockout) of associated with targeted disruption
10) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.47 Pain Relevance 0.24
Binding of IL-1 agonists to IL-1R1 requires association with an accessory protein to elicit downstream signal transduction that includes activation of nuclear factor-kappa B (NF?
IL-1 Binding (Binding) of associated with agonist
11) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0 Pain Relevance 0.33
IL-1 and leukocyte recruitment
IL-1 Binding (recruitment) of in leukocyte
12) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.80 Pain Relevance 0.41
A second 68 kDa receptor, the type II IL-1 receptor (IL-1RII), may serve as a decoy as it binds all IL-1 ligands but lacks an intracellular domain and has no demonstrated signaling function [12].
IL-1 Binding (binds) of
13) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.18 Pain Relevance 0.34
A number of studies have demonstrated that administration of IL-1?
IL-1 Binding (administration) of
14) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.44 Pain Relevance 0.31
While all known biological functions of IL-1 are attributable to IL-1 interactions with IL-1R1, some studies suggest that alternate functional IL-1 receptors may exist in the CNS [10,11].
IL-1 Binding (interactions) of associated with central nervous system
15) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0 Pain Relevance 0.27
IL-1 elevation is now recognized as a critical component of the brain's patterned response to insults, termed neuroinflammation, and of leukocyte recruitment to the CNS.
IL-1 Binding (recognized) of in brain associated with central nervous system
16) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2335091 Disease Relevance 0.61 Pain Relevance 0.23
In part they appear to mediate their effects due to their ability to suppress the release of cytokines such as TNF alpha and IL-1 from macrophages, as well as the binding of these cytokines to high-affinity receptors on target cells involved in the inflammation process.
IL-1 Binding (binding) of in macrophages associated with inflammation and cytokine
17) Confidence 0.29 Published 1996 Journal Int J Tissue React Section Abstract Doc Link 9063766 Disease Relevance 0.45 Pain Relevance 0.32
Ether-laparotomy stress did not affect [125I]IL-1 alpha binding in hippocampus, spleen and testis at any time after the stress.
IL-1 Binding (binding) of in testis associated with stress and hippocampus
18) Confidence 0.28 Published 1994 Journal Brain Res. Section Abstract Doc Link 7827996 Disease Relevance 0.88 Pain Relevance 0.05
In contrast, [125I]interleukin-1 (IL-1)alpha binding was significantly increased in the pituitary at 2 h after the stress and tended to be higher than non-stressed levels at 6 h after the stress but was not statistically significant.
IL-1 Binding (binding) of in pituitary associated with stress
19) Confidence 0.28 Published 1994 Journal Brain Res. Section Abstract Doc Link 7827996 Disease Relevance 0.90 Pain Relevance 0.04
Intriguingly, IL-1?
IL-1 Binding (Intriguingly) of
20) Confidence 0.24 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.78 Pain Relevance 0.60

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