INT256077

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
extracellular region (Serpina3k) response to stress (Ca2) cytoplasm (Ca2)
Serpina3k (Rattus norvegicus)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 26 99.36 Very High Very High Very High
Necrosis 15 68.16 Quite High
Death 24 50.00 Quite Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Nerve Degeneration 4 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 3 5.00 Very Low Very Low Very Low
Retina Disease 3 5.00 Very Low Very Low Very Low
Retinoblastoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Correlated with their effects on Ca2+, MTT assay demonstrated that SERPINA3K, U73122 and BAPTA, but not U0126 and Wortmannin, had protective effects on cell viability under the H2O2 stress (Fig. 6B), suggesting that the reduction of intracellular Ca2+ induced by SERPINA3K is not through the ERK or PI3K pathways.
SERPINA3K Positive_regulation (induced) of Gene_expression (reduction) of Ca2 associated with stress
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605247 Disease Relevance 0.17 Pain Relevance 0

General Comments

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