INT25608

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2011
Negated 5
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 27.76
Pain Relevance 10.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
thymocyte 4
neutrophil 4
macrophages 2
pore 2
articular cartilage 2
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 804 100.00 Very High Very High Very High
cytokine 705 100.00 Very High Very High Very High
chemokine 108 100.00 Very High Very High Very High
Hippocampus 52 100.00 Very High Very High Very High
antagonist 47 99.60 Very High Very High Very High
Substantia nigra 7 99.28 Very High Very High Very High
anakinra 30 99.12 Very High Very High Very High
Opioid 1 99.10 Very High Very High Very High
Dopamine 61 99.04 Very High Very High Very High
rheumatoid arthritis 420 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 931 100.00 Very High Very High Very High
Keratitis 184 100.00 Very High Very High Very High
Cognitive Disorder 51 100.00 Very High Very High Very High
Alzheimer's Dementia 376 99.84 Very High Very High Very High
Drug Induced Neurotoxicity 62 99.80 Very High Very High Very High
Necrosis 40 99.48 Very High Very High Very High
Crystal Associated Disease 83 99.44 Very High Very High Very High
Injury 300 98.76 Very High Very High Very High
Apoptosis 132 98.76 Very High Very High Very High
Rheumatoid Arthritis 423 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These morphological characteristics and pattern of distribution closely resemble that ordinarily reported.37 Although no significant treatment effects were observed in the middle and caudal levels of the hippocampus, there was a trend towards a cytokine-induced reduction of BrdU labelling, such that in the middle hippocampal region, IL-1?
Neg (no) Regulation (effects) of Gene_expression (reduction) of IL-1 in hippocampus associated with hippocampus and cytokine
1) Confidence 0.44 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695223 Disease Relevance 0.24 Pain Relevance 0.23
Similar results were obtained with NF177 (Fig. 5), reaching higher inhibition effects using PAF and IL-1-?
Regulation (effects) of Gene_expression (using) of IL-1
2) Confidence 0.44 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.20 Pain Relevance 0.11
The absence of an effect on IL-1 production was confirmed by quantitation of intracellular IL-1 alpha using goat anti-IL-1 alpha antibody and by quantitation of supernatant IL-1 receptor competition assay.
Regulation (effect) of Gene_expression (production) of IL-1
3) Confidence 0.42 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0 Pain Relevance 0
The role of prostaglandins in the regulation of lipopolysaccharide (LPS)-induced interleukin-1 (IL-1) production by murine C3H/HeN resident peritoneal macrophages was studied.
Regulation (regulation) of Gene_expression (production) of IL-1 in peritoneal macrophages
4) Confidence 0.42 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0 Pain Relevance 0
Increased expression of IL-1RII, the biologically inactive "decoy" IL-1 receptor, has been demonstrated following injection of IL-1?
Regulation (demonstrated) of Gene_expression (injection) of IL-1
5) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.10 Pain Relevance 0.12
Despite this evidence pointing toward an important function of IL-1 in AD pathogenesis, a recent study in the Tg2576 AD mouse model failed to detect any influence of IL-1R1 knockout on either A?
Regulation (pointing) of Gene_expression (function) of IL-1 associated with targeted disruption and alzheimer's dementia
6) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.78 Pain Relevance 0.03
Despite this evidence pointing toward an important function of IL-1 in AD pathogenesis, a recent study in the Tg2576 AD mouse model failed to detect any influence of IL-1R1 knockout on either A?
Regulation (important) of Gene_expression (function) of IL-1 associated with targeted disruption and alzheimer's dementia
7) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.77 Pain Relevance 0.03
induced neurotoxicity has been reported following single bolus injection or adenoviral mediated expression of IL-1?
Regulation (reported) of Gene_expression (expression) of IL-1 associated with drug induced neurotoxicity
8) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.94 Pain Relevance 0.28
In addition, single bolus injection or parenchymal expression of IL-1?
Regulation (injection) of Gene_expression (expression) of IL-1
9) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.86 Pain Relevance 0.49
Increased expression of IL-1RII, the biologically inactive "decoy" IL-1 receptor, has been demonstrated following injection of IL-1?
Regulation (demonstrated) of Gene_expression (expression) of IL-1RII
10) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.14 Pain Relevance 0.14
The effectiveness of IL-1 inhibition in suppressing the symptoms of acute gout was assessed in 10 patients who could not tolerate or did not respond to standard antiinflammatory treatments.
Regulation (effectiveness) of Gene_expression (inhibition) of IL-1 associated with inflammation and crystal associated disease
11) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 1.07 Pain Relevance 0.29
Thus, in this system, PGE2 has no effect on IL-1 synthesis, but rather has a direct inhibitory effect on thymocyte proliferation.
Neg (no) Regulation (effect) of Gene_expression (synthesis) of IL-1 in thymocyte
12) Confidence 0.25 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0.09 Pain Relevance 0.09
Further dilutions of the drug-treated supernatants gave thymocyte proliferation responses which were indistinguishable from control cultures and, correspondingly, had identical values for IL-1 production.
Regulation (values) of Gene_expression (production) of IL-1 in thymocyte
13) Confidence 0.25 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0 Pain Relevance 0
The level of PAR-1 protein expression after IL-1?
Regulation (level) of Gene_expression (expression) of IL-1
14) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.67 Pain Relevance 0.07
Furthermore, LPS-induced IL-1 production by macrophages (in the absence of added beta-endorphin) was also partially inhibited following treatment with naloxone, suggesting that opioids derived from activated macrophages may also modulate IL-1 generation and secretion.
Regulation (modulate) of Gene_expression (generation) of IL-1 in macrophages associated with narcan and opioid
15) Confidence 0.24 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.32
Targeting IL-1 ameliorates the cognitive abnormality by reducing microglia but does not affect HMGB1
Neg (not) Regulation (affect) of Gene_expression (Targeting) of IL-1 in microglia associated with cognitive disorder
16) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.90 Pain Relevance 0.30
and CXCL-1/KC hypernociceptive roles in carrageenin inflammation were demonstrated to be, at least in part, dependent on the production of IL-1?
Regulation (dependent) of Gene_expression (production) of IL-1 associated with inflammation
17) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.75 Pain Relevance 0.31
The persistence of neutrophil brain infiltrates was accompanied by high levels of IL-1?
Regulation (accompanied) of Gene_expression (levels) of IL-1 in neutrophil
18) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2682662 Disease Relevance 1.57 Pain Relevance 0.18
The RT-QPCR analysis confirmed that neutrophil depletion in the mice significantly decreased, but did not completely abrogate the upregulation of the aforementioned genes (including S100A8, S100A9, IL-1?
Regulation (upregulation) of Gene_expression (including) of IL-1 in neutrophil
19) Confidence 0.09 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.50 Pain Relevance 0.12
by modulating cellular expression of IL-1 receptor and/or IL-1 receptor antagonist (IL-1RA) and/or regulating signal transducer and activator of transcription dependent signalling through nuclear factor ?
Regulation (modulating) of Gene_expression (expression) of IL-1 associated with antagonist
20) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.91 Pain Relevance 0.86

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