INT25609

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Context Info
Confidence 0.80
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 10.66
Pain Relevance 6.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1f5) extracellular region (Il1f5) molecular_function (Il1f5)
biological_process (Il1f5)
Anatomy Link Frequency
platelets 2
neutrophils 2
macrophages 1
bone marrow 1
peritoneal macrophages 1
Il1f5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 123 100.00 Very High Very High Very High
cytokine 16 100.00 Very High Very High Very High
narcan 7 99.60 Very High Very High Very High
Enkephalin 10 99.42 Very High Very High Very High
Acute pain 1 99.04 Very High Very High Very High
dexamethasone 3 98.68 Very High Very High Very High
antinociception 8 98.44 Very High Very High Very High
Central nervous system 32 98.24 Very High Very High Very High
Pain 34 98.20 Very High Very High Very High
Neuropeptide 3 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 144 100.00 Very High Very High Very High
Cancer 29 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Dehydration 7 99.42 Very High Very High Very High
Pain 32 99.04 Very High Very High Very High
Hyperalgesia 7 98.80 Very High Very High Very High
Pressure And Volume Under Development 32 98.24 Very High Very High Very High
Lymphatic System Cancer 3 97.96 Very High Very High Very High
Urological Neuroanatomy 3 97.84 Very High Very High Very High
Rheumatoid Arthritis 6 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By thymocyte proliferation method, we herein report that methionine-enkephalin over a wide range of concentrations (1 pmol-0.1 mumol/L) significantly increases both extracellular interleukin-1 release and intracellular interleukin-1 production from peritoneal macrophages induced by lipopolysaccharide in mice.
Localization (release) of interleukin-1 in thymocyte associated with enkephalin
1) Confidence 0.80 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.62
The results suggest that methionine-enkephalin mediates the enhancement of interleukin-1 synthesis and release as well, and that the effect is not mediated through classical opioid receptors.
Localization (release) of interleukin-1 associated with opioid receptor and enkephalin
2) Confidence 0.70 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.64
The latter findings are consistent with a modulatory role for adrenergic activation on interleukin-1 release stimulated by endotoxicity.
Localization (release) of interleukin-1
3) Confidence 0.47 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9298510 Disease Relevance 0.17 Pain Relevance 0.26
Interleukin-1 secretion by peripheral blood monocytes and synovial macrophages from patients with rheumatoid arthritis.
Localization (secretion) of Interleukin-1 in monocytes associated with rheumatoid arthritis
4) Confidence 0.44 Published 1987 Journal J. Rheumatol. Section Title Doc Link 3494848 Disease Relevance 0.59 Pain Relevance 0.34
Postoperative incisional pain is characterized by persistent acute pain in the area of the cut, and is associated with release of proinflammatory cytokines, including interleukin-1 (IL-1), which play important hyperalgesic and allodynic roles in various inflammatory conditions.
Localization (release) of interleukin-1 associated with pain, hyperalgesia, inflammation, acute pain and cytokine
5) Confidence 0.31 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18442892 Disease Relevance 0.77 Pain Relevance 0.49
A glucocorticoid (dexamethasone), two cyclooxygenase inhibitors (indomethacin, piroxicam) and an interleukin-1 (IL-1) release inhibitor (IX 207-887, Sandoz) all reduced edema and MPO activity as well.
Localization (release) of interleukin-1 associated with pressure and volume under development, urological neuroanatomy and dexamethasone
6) Confidence 0.24 Published 1993 Journal Agents Actions Section Abstract Doc Link 8304241 Disease Relevance 0.98 Pain Relevance 0.47
Previous studies from this laboratory had shown that exposure of mice to cold water stress leads to an increase in the secretion of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF alpha) from their peritoneal macrophages.
Localization (secretion) of interleukin-1 in peritoneal macrophages associated with necrosis, cancer and dehydration
7) Confidence 0.18 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.68 Pain Relevance 0.15
Beta-endorphin regulates interleukin 1 production and release by murine bone marrow macrophages.
Localization (release) of interleukin 1 in macrophages associated with narcan
8) Confidence 0.18 Published 1989 Journal Int. Immunol. Section Title Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.31
Because interleukin-1 has been demonstrated to be a potent releaser of corticotropin-releasing factor (CRF) from the hypothalamus, we were interested to see whether CRF is involved in the antinociception induced by rHu-IL-1 alpha.
Localization (releaser) of interleukin-1 in hypothalamus associated with antinociception
9) Confidence 0.15 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8365458 Disease Relevance 0 Pain Relevance 0.57
Because it has been described that P-TR regulate thymocyte proliferation in vitro via the secretion of both interleukin 1 and PGE2, these results suggest that anti-inflammatory agents may be able to modulate the thymic microenvironment and, consequently, thymocyte proliferation.
Localization (secretion) of interleukin 1 in PGE2 associated with inflammation
10) Confidence 0.15 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3998470 Disease Relevance 0.18 Pain Relevance 0.20
There is substantial evidence that inflammation, such as neutrophil infiltration and release of interleukin-1 and tumor necrosis factor-?
Localization (release) of interleukin-1 in neutrophil associated with necrosis, inflammation and cancer
11) Confidence 0.06 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1142190 Disease Relevance 1.25 Pain Relevance 0.46
At the sites of inflammation, neutrophils may release PK2 that can subsequently induce the release of proinflammatory cytokines like interleukin-1 and interleukin-12 from macrophage or other cells [15].
Localization (release) of interleukin-1 in neutrophils associated with inflammation and cytokine
12) Confidence 0.06 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.16 Pain Relevance 0.87
These compounds can suppress antigen and mitogen-induced lymphocyte proliferation, natural-killer cell cytotoxicity, histamine release by mast cells, interleukin-1 (IL-1) secretion by human monocytes and the action of PAF on platelets [47].
Localization (release) of interleukin-1 in platelets
13) Confidence 0.05 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2810220 Disease Relevance 0.79 Pain Relevance 0.40
These compounds can suppress antigen and mitogen-induced lymphocyte proliferation, natural-killer cell cytotoxicity, histamine release by mast cells, interleukin-1 (IL-1) secretion by human monocytes and the action of PAF on platelets [47].
Localization (secretion) of interleukin-1 in platelets
14) Confidence 0.05 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2810220 Disease Relevance 0.74 Pain Relevance 0.37
In fact, receptors for inflammatory cytokines and bacterial fragments are constitutively expressed in cells within the sensory CVOs and the release of pro-inflammatory cytokines such as interleukin-1 or TNF-?
Localization (release) of interleukin-1 associated with inflammation and cytokine
15) Confidence 0.04 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.80 Pain Relevance 0.46
It is known that interleukin-1 (IL-1), interleukin-5 (IL-5), NFkB, granulocyte colony stimulating factor, tumor necrosis factor and many other cytokines are released from the HRS cells (1,28).
Localization (released) of interleukin-1 in granulocyte associated with necrosis, cancer and cytokine
16) Confidence 0.02 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 1.07 Pain Relevance 0.10
Intraperitoneal injection of the alcoholic extract of T. cordifolia has been shown to Dalton's lymphoma (DL) bearing mice e stimulated macrophage functions likephagocytosis, antigen-presenting ability and secretion of Interleukin-1 (IL-1), tumour necrosis factor (TNF) and Reference Nutrient Intake (RNI) as well as slowed tumor growth and increased lifespan of the tumor-bearing host.[64] T. cordifolia was has beem shown effective in several other tumour models including Ehrlich ascites carcinoma (EAC) in mice.[65] It induces proliferation and myeloid differentiation of bone marrow precursor cells in a tumor-bearing host,[66] activates tumor-associated macrophages-derived dendritic cells,[67] is effective against various cancers,[68] killing the cancer cells very effectively in vitro[6970] inhibits skin carcinogenesis in mice,[71] and inhibits experimental metastasis.[72] T. cordifolia may offer an alternative treatment strategy for cancer in combination with gamma radiation.[7374]

ANTIPYRETIC AND ANTI-INFECTIVE ACTIVITY

Localization (secretion) of Interleukin-1 in bone marrow associated with pressure and volume under development, necrosis, aging, lymphatic system cancer, cancer, carcinoma and metastasis
17) Confidence 0.01 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 1.49 Pain Relevance 0

General Comments

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