INT256120

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.81
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sirt5)
Anatomy Link Frequency
neurons 2
neuronal 1
Sirt5 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 8 87.68 High High
withdrawal 8 58.64 Quite High
agonist 24 58.00 Quite High
Inflammation 16 40.88 Quite Low
Neuritis 8 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 256 99.60 Very High Very High Very High
Toxicity 40 99.32 Very High Very High Very High
Stress 56 95.60 Very High Very High Very High
Neurodegenerative Disease 48 94.88 High High
Neuroblastoma 80 90.72 High High
Death 176 85.44 High High
Disease 24 61.48 Quite High
INFLAMMATION 16 40.88 Quite Low
Motor Neuron Diseases 8 39.52 Quite Low
Chromosomal Instability 8 37.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More work is necessary to delineate what factors and mechanisms determine the localization of SIRT5 within cells.
Spec (determine) Localization (localization) of SIRT5
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.51 Pain Relevance 0.07
SIRT3, SIRT4, and SIRT5 localize to the mitochondria and are therefore thought to play a role in energy metabolism and responses to oxidative stress [17].
Localization (localize) of SIRT5 associated with stress
2) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.18 Pain Relevance 0
SIRT5 is generally localized to both the nucleus and cytoplasm of CGNs and exerts a protective effect.
Localization (localized) of SIRT5 in CGNs
3) Confidence 0.47 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2605257 Disease Relevance 0.42 Pain Relevance 0
In a small proportion of these neurons, however, SIRT5 localized solely in mitochondria (Fig. 2C).
Localization (localized) of SIRT5 in neurons
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.51 Pain Relevance 0
An analysis of the relationship between subcellular localization and neuroprotection reveals that SIRT5 is protective when it localizes to the cytoplasm.
Localization (localizes) of SIRT5
5) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.52 Pain Relevance 0.03
In contrast to previous studies in which SIRT5 expression was restricted to mitochondria of non-neuronal cell types [17], in a majority of CGNs SIRT5 is widely distributed displaying nuclear, cytoplasmic and mitochondrial localization (Fig. 2C).
Localization (localization) of SIRT5 in neuronal
6) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.58 Pain Relevance 0
SIRT5 was generally localized in the mitochondria of HT-22 cells and was apoptotic.


Localization (localized) of SIRT5 associated with apoptosis
7) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2605257 Disease Relevance 0.56 Pain Relevance 0
In contrast, when localized to the mitochondria, SIRT5 promotes apoptosis (Fig. 1C).
Localization (localized) of SIRT5 associated with apoptosis
8) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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