INT256127

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Hist2h4) biological_process (Hist2h4)
Hist2h4 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 41 83.76 Quite High
Inflammation 2 70.48 Quite High
depression 4 35.28 Quite Low
ischemia 2 34.72 Quite Low
amygdala 2 23.24 Low Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 135 96.84 Very High Very High Very High
INFLAMMATION 2 70.48 Quite High
Anxiety Disorder 48 69.20 Quite High
Apoptosis 32 68.20 Quite High
Chromosomal Instability 1 66.80 Quite High
Mental Disorders 8 61.96 Quite High
Lifespan 1 58.24 Quite High
Convulsion 8 53.68 Quite High
Depression 4 35.28 Quite Low
Cv Unclassified Under Development 2 34.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, there were no alterations in the total levels of H3 and H4 histone acetylation after FC.
Gene_expression (levels) of H4
1) Confidence 0.02 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.33 Pain Relevance 0.03
There were no significant differences in the hippocampal levels of acetylated histone H4 at all 4 promoter regions among these 3 groups (Figure 3B).
Gene_expression (levels) of H4
2) Confidence 0.02 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.85 Pain Relevance 0.11
SIRT1, which has highest sequence similarity to yeast Sir2, is largely nuclear where it deacetylates histones H3 and H4 as well as transcription factors such as NF-?
Gene_expression (deacetylates) of H4
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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