INT256127

Context Info Confidence 0.02 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.59 Pain Relevance 0.18

cellular_component (Hist2h4) biological_process (Hist2h4)

Hist2h4 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 41 83.76 Inflammation 2 70.48 depression 4 35.28 ischemia 2 34.72 amygdala 2 23.24 long-term potentiation 6 5.00 agonist 3 5.00 anesthesia 2 5.00 withdrawal 1 5.00 Neuritis 1 5.00

Disease Link Frequency Relevance Heat Stress 135 96.84 INFLAMMATION 2 70.48 Anxiety Disorder 48 69.20 Apoptosis 32 68.20 Chromosomal Instability 1 66.80 Mental Disorders 8 61.96 Lifespan 1 58.24 Convulsion 8 53.68 Depression 4 35.28 Cv Unclassified Under Development 2 34.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, there were no alterations in the total levels of H3 and H4 histone acetylation after FC.

Gene_expression (levels) of H4

1) Confidence 0.02 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.33 Pain Relevance 0.03

There were no significant differences in the hippocampal levels of acetylated histone H4 at all 4 promoter regions among these 3 groups (Figure 3B).

Gene_expression (levels) of H4

2) Confidence 0.02 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.85 Pain Relevance 0.11

SIRT1, which has highest sequence similarity to yeast Sir2, is largely nuclear where it deacetylates histones H3 and H4 as well as transcription factors such as NF-?

Gene_expression (deacetylates) of H4

3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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