INT256129

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
neurons 2
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 100.00 Very High Very High Very High
Inflammation 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 32 99.78 Very High Very High Very High
Neurodegenerative Disease 6 85.92 High High
Death 22 75.36 Quite High
Toxicity 5 23.92 Low Low
Neuroblastoma 10 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Optic Neuritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several investigators have found that the anti-apoptotic effect of SIRT1 overexpression in neurons as well as non-neuronal cell types is mimicked by chemical agonists of SIRT1 and can be inhibited by pharmacological inhibitors of this sirtuin [11], [31]–[36].
Negative_regulation (inhibited) of Gene_expression (overexpression) of SIRT1 in neurons associated with agonist and apoptosis
1) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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