INT25613

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 13.29
Pain Relevance 10.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1f5) extracellular region (Il1f5) molecular_function (Il1f5)
biological_process (Il1f5)
Anatomy Link Frequency
peritoneal macrophages 5
macrophages 4
4T1 2
thymocyte 2
platelet 1
Il1f5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 182 100.00 Very High Very High Very High
cytokine 77 100.00 Very High Very High Very High
antinociception 8 99.98 Very High Very High Very High
Neuropeptide 10 99.92 Very High Very High Very High
Morphine 4 99.92 Very High Very High Very High
Enkephalin 41 99.90 Very High Very High Very High
narcan 17 99.56 Very High Very High Very High
Opioid 4 99.18 Very High Very High Very High
Pain 4 98.62 Very High Very High Very High
opioid receptor 10 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 233 100.00 Very High Very High Very High
INFLAMMATION 196 100.00 Very High Very High Very High
Necrosis 33 100.00 Very High Very High Very High
Disease 143 99.48 Very High Very High Very High
Influenza Virus Infection 7 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 20 98.76 Very High Very High Very High
Metastasis 183 98.00 Very High Very High Very High
Thrombosis 2 94.52 High High
Pleurisy 1 94.24 High High
Amyloid Plaque 9 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-1 production was also elevated following ip methionine-enkephalin into mice.
Gene_expression (production) of Interleukin-1 associated with enkephalin
1) Confidence 0.77 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.65
By thymocyte proliferation method, we herein report that methionine-enkephalin over a wide range of concentrations (1 pmol-0.1 mumol/L) significantly increases both extracellular interleukin-1 release and intracellular interleukin-1 production from peritoneal macrophages induced by lipopolysaccharide in mice.
Gene_expression (production) of interleukin-1 in thymocyte associated with enkephalin
2) Confidence 0.77 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.63
The results suggest that methionine-enkephalin mediates the enhancement of interleukin-1 synthesis and release as well, and that the effect is not mediated through classical opioid receptors.
Gene_expression (synthesis) of interleukin-1 associated with opioid receptor and enkephalin
3) Confidence 0.77 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.64
Naloxone, having no effect per se on interleukin-1 production, does not block the enhancing effect of the neuropeptide.
Gene_expression (production) of interleukin-1 associated with neuropeptide and narcan
4) Confidence 0.77 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.64
Enhancement of interleukin-1 production in mouse peritoneal macrophages by methionine-enkephalin.
Gene_expression (production) of interleukin-1 in peritoneal macrophages associated with enkephalin
5) Confidence 0.77 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.64
Interestingly, it depressed interleukin-1 production, known to play a major role in the inflammatory process.
Gene_expression (production) of interleukin-1 associated with inflammation
6) Confidence 0.73 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784787 Disease Relevance 0.17 Pain Relevance 0.05
Phagocytosis-induced chemiluminescence of peritoneal macrophages was also enhanced whereas interleukin-1 production by these cells was depressed, but without concomitant modification in interleukin-2 production by T-cells.
Gene_expression (production) of interleukin-1 in T-cells
7) Confidence 0.73 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784787 Disease Relevance 0.15 Pain Relevance 0.23
By thymocyte proliferation method, we herein report that methionine-enkephalin over a wide range of concentrations (1 pmol-0.1 mumol/L) significantly increases both extracellular interleukin-1 release and intracellular interleukin-1 production from peritoneal macrophages induced by lipopolysaccharide in mice.
Gene_expression (production) of interleukin-1 in thymocyte associated with enkephalin
8) Confidence 0.60 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2610000 Disease Relevance 0 Pain Relevance 0.63
Blood monocytes and synovial fluid and tissue macrophages were examined for their ability to produce interleukin-1 (IL-1) measured in a mouse thymocyte proliferation assay.
Gene_expression (produce) of interleukin-1 in Blood
9) Confidence 0.42 Published 1987 Journal J. Rheumatol. Section Abstract Doc Link 3494848 Disease Relevance 0.57 Pain Relevance 0.33
Effect of morphine on interleukin-1 and tumor necrosis factor alpha production from mouse peritoneal macrophages in vitro.
Gene_expression (production) of interleukin-1 in peritoneal macrophages associated with necrosis, cancer, narcan and morphine
10) Confidence 0.26 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 8701766 Disease Relevance 0.20 Pain Relevance 0.25
METHODS: The productions of interleukin-1 (IL-1) and tumor necrosis factor (TNF-alpha) from PM phi under various concentrations of morphine with or without naloxone were measured by testing thymocyte proliferation and L929 cell lysis in vitro.
Gene_expression (productions) of interleukin-1 in L929
11) Confidence 0.26 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 8701766 Disease Relevance 0 Pain Relevance 0
Monocytes and tissue macrophages produce at least two groups of protein mediators of inflammation, interleukin 1 (IL-1) and tumor necrosis factor (TNF).
Gene_expression (produce) of interleukin 1 in macrophages associated with necrosis, inflammation and cancer
12) Confidence 0.23 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12510845 Disease Relevance 0.49 Pain Relevance 0.21
The role of the neuropeptide beta-endorphin on interleukin 1 (IL-1) production by murine bone marrow-derived macrophages was assessed.
Gene_expression (production) of interleukin 1 in macrophages associated with neuropeptide
13) Confidence 0.19 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.12
Beta-endorphin regulates interleukin 1 production and release by murine bone marrow macrophages.
Gene_expression (production) of interleukin 1 in macrophages associated with narcan
14) Confidence 0.19 Published 1989 Journal Int. Immunol. Section Title Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.31
Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation.
Gene_expression (production) of Interleukin-1 associated with inflammation
15) Confidence 0.19 Published 1993 Journal Agents Actions Section Title Doc Link 8213352 Disease Relevance 0.71 Pain Relevance 0.36
The severity of the operative stress was assessed by serum levels of epinephrine and C-reactive protein at 0, 1, 2, 4, and 6 hours and compared with systemic levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha.
Gene_expression (levels) of interleukin-1
16) Confidence 0.19 Published 1996 Journal Reg Anesth Section Body Doc Link 8896011 Disease Relevance 0.08 Pain Relevance 0
AD mice that constitutively express interleukin-1 in the brain, or that are deficient in peripheral mononuclear phagocyte transforming growth factor-beta signaling, have increased microglia accumulation around beta-amyloid plaques and reduced AD-like pathology.
Gene_expression (express) of interleukin-1 in microglia associated with disease and amyloid plaque
17) Confidence 0.19 Published 2008 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 18835047 Disease Relevance 1.11 Pain Relevance 0.30
We found that the aqueous extract of N. procerum leaves (leaf aqueous extract; LAE) inhibits the neutrophil migration, production of inflammatory cytokines interleukin-1 and -6 (IL-1 and IL-6) and the generation of prostaglandin E2 (PGE2) in LPS-induced pleural inflammation in mice.
Gene_expression (production) of interleukin-1 in neutrophil associated with inflammation and cytokine
18) Confidence 0.16 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15930736 Disease Relevance 0.69 Pain Relevance 0.43
The role of prostaglandins in the regulation of lipopolysaccharide (LPS)-induced interleukin-1 (IL-1) production by murine C3H/HeN resident peritoneal macrophages was studied.
Gene_expression (production) of interleukin-1 in peritoneal macrophages
19) Confidence 0.15 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0 Pain Relevance 0
The pharmacologic regulation of interleukin-1 production: the role of prostaglandins.
Gene_expression (production) of interleukin-1
20) Confidence 0.15 Published 1988 Journal Cell. Immunol. Section Title Doc Link 2968844 Disease Relevance 0 Pain Relevance 0

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