INT256134

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
nucleus 4
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 4 36.72 Quite Low
Inflammation 9 23.52 Low Low
agonist 12 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 88 99.16 Very High Very High Very High
Repression 13 98.32 Very High Very High Very High
Stress 29 90.96 High High
Apoptosis 130 80.12 Quite High
Disease 12 77.60 Quite High
Motor Neuron Diseases 4 76.00 Quite High
Toxicity 20 73.04 Quite High
Neuroblastoma 40 66.40 Quite High
Neurodegenerative Disease 24 65.24 Quite High
Optic Neuritis 4 37.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like SIRT1, SIRT6 and SIRT7 are nuclear proteins although the three proteins display distinct sub-nuclear localization patterns; SIRT6 associates with heterochromatin, SIRT7 localizes to nucleoli, whereas SIRT1 is largely associated with euchromatin within the nucleus [17].
Localization (localizes) of SIRT1 in nucleus
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.59 Pain Relevance 0
Although generally present in the nucleus, nucleo-cytoplasmic shuttling of SIRT1 has recently been described [8], [27].
Localization (present) of SIRT1 in nucleus
2) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.70 Pain Relevance 0
In CGNs, ectopically-expressed SIRT1 localizes to the nucleus in both HK and LK conditions (Fig. 2A).
Localization (localizes) of SIRT1 in nucleus
3) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.61 Pain Relevance 0
Although generally present in the nucleus, nucleo-cytoplasmic shuttling of SIRT1 has recently been described [8], [27].
Localization (shuttling) of SIRT1 in nucleus
4) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.64 Pain Relevance 0
A specific example is a study demonstrating that Sirt1 deacetylation of AP1 modulates its function and causes repression of the Cox2 gene [19].
Localization (deacetylation) of Sirt1 associated with repression
5) Confidence 0.40 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.45 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox