INT256165

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt6, Sirt1) nucleus (Sirt6, Sirt1) cell differentiation (Sirt1)
nuclear envelope (Sirt1) histone binding (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
nucleus 1
Sirt6 (Mus musculus)
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 1 31.52 Quite Low
Inflammation 2 30.28 Quite Low
agonist 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 94.60 High High
Death 22 76.08 Quite High
Disease 3 72.40 Quite High
Motor Neuron Diseases 1 70.80 Quite High
Toxicity 5 67.84 Quite High
Optic Neuritis 1 32.00 Quite Low
INFLAMMATION 2 30.28 Quite Low
Apoptosis 32 28.00 Quite Low
Chromosomal Instability 1 26.60 Quite Low
Lifespan 1 18.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like SIRT1, SIRT6 and SIRT7 are nuclear proteins although the three proteins display distinct sub-nuclear localization patterns; SIRT6 associates with heterochromatin, SIRT7 localizes to nucleoli, whereas SIRT1 is largely associated with euchromatin within the nucleus [17].
SIRT6 Binding (associates) of SIRT1 in nucleus
1) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.58 Pain Relevance 0

General Comments

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