INT2562

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.92
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gusb) lysosome (Gusb)
Anatomy Link Frequency
ileum 1
leucocyte 1
caecum 1
colon 1
rectum 1
Gusb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 94.36 High High
alcohol 1 94.16 High High
halothane 1 93.92 High High
bradykinin 1 90.92 High High
cINOD 3 86.88 High High
Morphine 8 86.28 High High
Inflammation 14 82.80 Quite High
Analgesic 1 76.48 Quite High
Arthritis 1 75.00 Quite High
cytokine 2 71.84 Quite High
Disease Link Frequency Relevance Heat
Crystal Associated Disease 6 98.92 Very High Very High Very High
Shock 4 98.20 Very High Very High Very High
Diabetes Mellitus 46 96.72 Very High Very High Very High
Obesity 1 95.32 Very High Very High Very High
Cancer 1 92.80 High High
Necrosis 2 92.32 High High
Body Weight 4 91.44 High High
Neuropathic Pain 1 91.36 High High
Ocular Toxicity (including Many Sub-types) 1 90.76 High High
Diabetes Complications 1 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the control group of ten patients who were not treated with allopurinol, serum uric acid increased, the lactate/pyruvate ratio rose and beta-glucuronidase activity increased respectively after open heart surgery as in shock.
Positive_regulation (increased) of beta-glucuronidase in heart associated with shock
1) Confidence 0.69 Published 1979 Journal Jpn. Circ. J. Section Abstract Doc Link 470098 Disease Relevance 0.66 Pain Relevance 0.14
The increased beta-glucuronidase and lactate dehydrogenase level were observed in untreated monosodium urate crystal incubated polymorphonuclear leucocytes.
Positive_regulation (increased) of beta-glucuronidase in polymorphonuclear leucocytes associated with crystal associated disease
2) Confidence 0.60 Published 2006 Journal Chem. Biol. Interact. Section Abstract Doc Link 17084827 Disease Relevance 0.60 Pain Relevance 0.21
The glycoside was more potent than troxerutin on capillary permeability increased by histamine and exerted inhibitory effects on protein exudation, leucocyte migration and beta-glucuronidase activity in the carrageenan air pouch, thereby showing some difference from indomethacin.
Positive_regulation (exerted) of beta-glucuronidase in leucocyte
3) Confidence 0.44 Published 1987 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2886616 Disease Relevance 0.32 Pain Relevance 0.42
The activity of beta-glucuronidase in intestinal cell homogenates is constant along the duodenum and jejunum but increases throughout the terminal ileum, caecum, colon and rectum.
Positive_regulation (increases) of beta-glucuronidase in rectum
4) Confidence 0.36 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3931647 Disease Relevance 0 Pain Relevance 0.16
A dose-independent increase of beta-glucuronidase activity and decrease of superoxide dismutase activity were observed in both fibers.
Neg (independent) Positive_regulation (increase) of beta-glucuronidase
5) Confidence 0.27 Published 2002 Journal Inhal Toxicol Section Abstract Doc Link 12028805 Disease Relevance 0.26 Pain Relevance 0.13
Besides, it has been shown that the alloxan injection causes a significant increase in the activity of several enzymes, such as beta-glucuronidase, N-acetyl-beta-glucosaminidase, lysosomal acid phosphatase, leucine aminopeptidase, and cathepsin D [29].
Positive_regulation (increase) of beta-glucuronidase
6) Confidence 0.14 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC443509 Disease Relevance 1.09 Pain Relevance 0.05
The activity of beta-glucuronidase in intestinal cell homogenates is constant along the duodenum and jejunum but increases throughout the terminal ileum, caecum, colon and rectum.
Positive_regulation (increases) of beta-glucuronidase in ileum
7) Confidence 0.12 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3931647 Disease Relevance 0 Pain Relevance 0.16
The activity of beta-glucuronidase in intestinal cell homogenates is constant along the duodenum and jejunum but increases throughout the terminal ileum, caecum, colon and rectum.
Positive_regulation (increases) of beta-glucuronidase in colon
8) Confidence 0.12 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3931647 Disease Relevance 0 Pain Relevance 0.16
The activity of beta-glucuronidase in intestinal cell homogenates is constant along the duodenum and jejunum but increases throughout the terminal ileum, caecum, colon and rectum.
Positive_regulation (increases) of beta-glucuronidase in caecum
9) Confidence 0.12 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3931647 Disease Relevance 0 Pain Relevance 0.16

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