INT25621

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Context Info
Confidence 0.20
First Reported 1989
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.23
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cfb) peptidase activity (Cfb) extracellular space (Cfb)
extracellular region (Cfb)
Anatomy Link Frequency
cleavage 1
internal 1
nucleus 1
CII 1
salivary gland 1
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Arthritis 40 99.60 Very High Very High Very High
Inflammation 63 88.64 High High
rheumatoid arthritis 52 82.56 Quite High
ischemia 14 81.00 Quite High
anesthesia 5 66.72 Quite High
projection neuron 1 56.16 Quite High
Inflammatory response 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 42 99.60 Very High Very High Very High
Targeted Disruption 24 95.48 Very High Very High Very High
Apoptosis 14 94.24 High High
INFLAMMATION 71 88.64 High High
Death 24 88.36 High High
Rheumatoid Arthritis 52 82.56 Quite High
Cv Unclassified Under Development 14 81.00 Quite High
Hypoxia 1 80.48 Quite High
Neurodegenerative Disease 25 79.40 Quite High
Hemolysis 57 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All mice used in this study were screened by Western blot analysis for the presence of factor B in serum, as an internal quality control (Fig. 1).
Localization (presence) of factor B in internal
1) Confidence 0.20 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 0.26 Pain Relevance 0.07
Genetic deletion of C5, C3 or factor B in DBA/1 mice resulted in each case in mice being highly resistant to CIA induction [23,24] despite the presence of high titers of anti-CII antibodies.
Localization (deletion) of factor B in CII associated with arthritis
2) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.02 Pain Relevance 0.43
IxACs inhibit the cleavage of human C3 and factor B
Localization (cleavage) of factor B in cleavage
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.24 Pain Relevance 0.04
On the contrary, the formation of C3 convertase in the presence of properdin was strongly affected by IxACs.
Localization (presence) of properdin
4) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Alternatively, as birds and reptiles have not been studied as exhaustively as mammals, it cannot be ruled out that properdin is present in some species or lineages but not in others.
Neg (not) Localization (present) of properdin
5) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Localization of chromogranin A and B, beta-endorphin and enkephalins in the submandibular glands of mice.
Localization (Localization) of and B in submandibular glands associated with enkephalin
6) Confidence 0.08 Published 1989 Journal Shika Kiso Igakkai Zasshi Section Title Doc Link 2535263 Disease Relevance 0 Pain Relevance 0.52
The localization of chromogranin A and B, beta-endorphin, met-enkephalin and leu-enkephalin was immunocytochemically investigated in the submandibular salivary gland (SMG) and pancreas of male mice using different antibodies.
Spec (investigated) Localization (localization) of and B in salivary gland associated with enkephalin
7) Confidence 0.04 Published 1989 Journal Shika Kiso Igakkai Zasshi Section Abstract Doc Link 2535263 Disease Relevance 0 Pain Relevance 0.27
A number of simulations were performed for a wide range of fa, fb, M, N values.
Localization (range) of fb
8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628737 Disease Relevance 0 Pain Relevance 0
The activation of this pathway has been linked to the activation and nuclear translocation of nuclear factor-kB (NFkB), which once in the nucleus, can lead to the up-regulation of neuroprotective genes (e.g., the caspase inhibitors: X-linked inhibitor of apoptosis proteins, XIAP, and cellular inhibitor of apoptosis proteins-2, c-IAP2) [32].
Localization (translocation) of factor-kB in nucleus associated with apoptosis
9) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.71 Pain Relevance 0.07

General Comments

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