INT256229

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.96
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EDNRB) signal transducer activity (EDNRB)
Anatomy Link Frequency
liver 1
kidney 1
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 77.72 Quite High
Kinase C 2 72.92 Quite High
tolerance 7 67.96 Quite High
antagonist 45 5.00 Very Low Very Low Very Low
diabetic neuropathy 8 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Brush evoked pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 87.16 High High
Increased Venous Pressure Under Development 44 69.68 Quite High
Impaired Glucose Tolerance 6 67.96 Quite High
Diabetes Mellitus 106 62.76 Quite High
Pressure And Volume Under Development 11 62.00 Quite High
Pulmonary Hypertension 65 55.52 Quite High
Disease 18 32.64 Quite Low
Diabetic Foot Ulcer 8 26.48 Quite Low
Injury 4 15.16 Low Low
Stress 5 13.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several mechanisms are involved in the clearance of ET-1 from plasma, including endocytosis in the lungs, enzymatic degradation, degradation of the endothelin B-receptor-ligand complex, and enzymatic processes in the kidney and liver (Anggard et al 1989; Abassi et al 1992; Johnström et al 2005).
Protein_catabolism (degradation) of endothelin B-receptor-ligand in kidney
1) Confidence 0.64 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 0.38 Pain Relevance 0.03
ET-1 forms an insoluble bond with the ETB that is internalized and degraded (D’Orleans-Juste et al 2002).
Protein_catabolism (degraded) of ETB
2) Confidence 0.33 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.19 Pain Relevance 0.08
Several mechanisms are involved in the clearance of ET-1 from plasma, including endocytosis in the lungs, enzymatic degradation, degradation of the endothelin B-receptor-ligand complex, and enzymatic processes in the kidney and liver (Anggard et al 1989; Abassi et al 1992; Johnström et al 2005).
Protein_catabolism (degradation) of endothelin B-receptor-ligand in liver
3) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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