INT256260

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.20
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 68 100.00 Very High Very High Very High
central sensitization 16 99.78 Very High Very High Very High
nMDA receptor 22 98.66 Very High Very High Very High
amygdala 554 98.56 Very High Very High Very High
COX2 1 92.52 High High
Central nervous system 5 90.56 High High
Spinal cord 9 86.64 High High
Dynorphin 1 84.24 Quite High
Hippocampus 1 75.76 Quite High
Dorsal horn 1 63.12 Quite High
Disease Link Frequency Relevance Heat
Pain 80 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 6 97.76 Very High Very High Very High
Anxiety Disorder 30 71.64 Quite High
Ganglion Cysts 1 62.44 Quite High
INFLAMMATION 4 60.36 Quite High
Post Operative Pain 38 50.00 Quite Low
Vomiting 13 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, both the increase in stimulation intensity and LTP induction protocol (100?
Positive_regulation (increase) of LTP Binding (intensity) of
1) Confidence 0.03 Published 2008 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2605401 Disease Relevance 0.17 Pain Relevance 0.22
As expected, both the increase in stimulation intensity and LTP induction protocol (100?
Positive_regulation (stimulation) of LTP Binding (intensity) of
2) Confidence 0.03 Published 2008 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2605401 Disease Relevance 0.17 Pain Relevance 0.21
It is also known that NMDA receptors, essential for activity dependent central sensitization, also are necessary for the initiation of LTP, which has a role in the consolidation of memory.
Positive_regulation (necessary) of LTP Binding (initiation) of associated with pain, central sensitization and nmda receptor
3) Confidence 0.02 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2844689 Disease Relevance 0.86 Pain Relevance 1.46

General Comments

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