INT256268

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.92
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
LAD 1
dorsal 1
artery 1
amygdala 1
Lad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 1385 100.00 Very High Very High Very High
imagery 42 99.90 Very High Very High Very High
GABAergic 10 86.76 High High
ischemia 12 81.88 Quite High
depression 15 79.84 Quite High
Angina 6 6.52 Low Low
nMDA receptor 40 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
gABA 10 5.00 Very Low Very Low Very Low
Thalamus 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aneurism 2 95.68 Very High Very High Very High
Stress 14 82.92 Quite High
Cv Unclassified Under Development 14 81.88 Quite High
Anxiety Disorder 70 80.40 Quite High
Depression 15 79.84 Quite High
Anaerobic Bacterial Infections 15 79.52 Quite High
Body Weight 2 57.72 Quite High
Arrhythmias 2 Under Development 2 35.20 Quite Low
Arrhythmia Under Development 2 33.40 Quite Low
Disease 4 31.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This model establishes that following an auditory stimulus, thalamic activation of the LAd leads to recurrent excitatory activity within the LAd, and that this recurrent feedback is temporally coincident with subsequent cortical input into the LAd.
Positive_regulation (activation) of LAd associated with amygdala
1) Confidence 0.47 Published 2008 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2605401 Disease Relevance 0.16 Pain Relevance 0.85
Stimulation of LAd-i produced a direct FP response in LAd-s (Figure 7B).
Positive_regulation (Stimulation) of LAd-i associated with amygdala
2) Confidence 0.47 Published 2008 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2605401 Disease Relevance 0 Pain Relevance 0.62
We measured the changes within the LAd network when LTP was induced at the monosynaptic thalamic input.
Positive_regulation (induced) of LAd associated with amygdala
3) Confidence 0.34 Published 2008 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2605401 Disease Relevance 0.16 Pain Relevance 0.26
In addition, the model incorporates the results of the slice cut experiments together with the data from the LTP experiments, as well as our direct establishment of monosynaptic LAd-i to LAd-s connectivity and its heterosynaptic LTD response to LTP at thalamo-amygdala afferents.
Positive_regulation (establishment) of LAd-i in amygdala associated with amygdala
4) Confidence 0.34 Published 2008 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2605401 Disease Relevance 0 Pain Relevance 0.71
We next tested whether this ventro-dorsal connection is functional by recording FP evoked in the LAd-s in response to the stimulation of the LAd-i.
Positive_regulation (stimulation) of LAd-i in dorsal associated with amygdala
5) Confidence 0.32 Published 2008 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2605401 Disease Relevance 0 Pain Relevance 0.62
DMI was evaluated in the LAD territory during DSE.
Positive_regulation (evaluated) of LAD in LAD associated with imagery
6) Confidence 0.09 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2790124 Disease Relevance 0.31 Pain Relevance 0.24
To evaluate WMSI in the LAD artery territory, each ventricular segment of the LAD artery territory was scored on a five-point scale: 1=normal, 2=hypokinesis, 3=akinesis, 4=dyskinesis and 5=aneurysm.
Positive_regulation (segment) of LAD in artery associated with aneurism
7) Confidence 0.09 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2790124 Disease Relevance 0.29 Pain Relevance 0.26

General Comments

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