INT256282

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 19
Disease Relevance 17.61
Pain Relevance 16.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb2) cell adhesion (Efnb2) plasma membrane (Efnb2)
Anatomy Link Frequency
spinal cord 4
central nervous system 1
Nociceptor 1
dorsal horn 1
microglial cells 1
Efnb2 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 176 99.98 Very High Very High Very High
Spinal cord 474 99.92 Very High Very High Very High
nav1.8 240 99.84 Very High Very High Very High
Inflammation 154 99.56 Very High Very High Very High
Pain 388 99.52 Very High Very High Very High
Neuropathic pain 354 99.52 Very High Very High Very High
nMDA receptor 141 99.52 Very High Very High Very High
allodynia 147 99.36 Very High Very High Very High
Eae 258 99.32 Very High Very High Very High
intrathecal 67 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1082 100.00 Very High Very High Very High
INFLAMMATION 172 99.56 Very High Very High Very High
Neuropathic Pain 563 99.52 Very High Very High Very High
Pain 442 99.52 Very High Very High Very High
Injury 86 99.38 Very High Very High Very High
Inflammatory Pain 145 99.32 Very High Very High Very High
Cancer 76 99.26 Very High Very High Very High
Hyperalgesia 205 96.92 Very High Very High Very High
Skin Cancer 8 95.92 Very High Very High Very High
Nervous System Malformation 16 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present studies demonstrate that presynaptic ephrin-B2 expressed by Nav1.8+ nociceptors has an important role in regulating to the central nervous system in conditions of inflammatory and neuropathic pain.
Gene_expression (expressed) of ephrin-B2 in central nervous system associated with inflammation, nociceptor, neuropathic pain, central nervous system and nav1.8
1) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.55 Pain Relevance 0.63
m2 (see method) was 4.7 ± 0.8 (Day 3), 9.1 ± 0.3 (Day 7), 5.1 ± 0.2 (Day 14), 2.2 ± 0.1 (Day 26) in Efnb2fl/fl controls, and 4.9 ± 0.6 (Day 3), 6.2 ± 0.1 (Day 7), 3.4 ± 0.4 (Day 14), 1.4 ± 0.2 (Day 26) in Efnb2 CKO mice respectively.
Gene_expression (controls) of Efnb2fl associated with targeted disruption
2) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.61 Pain Relevance 0.40
However, the increased immunoreactivity of GFAP positive cells in spinal cord was similar between Efnb2 CKO mice and Efnb2fl/fl controls.
Gene_expression (controls) of Efnb2fl in spinal cord associated with targeted disruption and spinal cord
3) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.57 Pain Relevance 0.58
c-Fos expression in spinal cord of ephrin-B2 CKO mutants is diminished in inflammatory pain
Gene_expression (mutants) of ephrin-B2 in spinal cord associated with targeted disruption, eae and spinal cord
4) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.34 Pain Relevance 1.32
There were similar number of positvie microglial cells in sham animals (0.13 ± 0.04, Efnb2fl/fl controls; 0.02 ± 0.02, Efnb2 CKO) in 104 ?
Gene_expression (0.04) of Efnb2 CKO in microglial cells associated with targeted disruption
5) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.62 Pain Relevance 0.39
NR2B phosphorylation in spinal cord of ephrin-B2 CKO mutants is lost in some inflammatory pain models
Gene_expression (mutants) of ephrin-B2 in spinal cord associated with targeted disruption, eae and spinal cord
6) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.86 Pain Relevance 0.75
Intrathecal administration of ephrin-B2 siRNA decreased the expression of ephrin-B2 and mechanical allodynia after sciatic nerve crush [10].
Gene_expression (expression) of ephrin-B2 in sciatic nerve associated with allodynia, sciatic nerve and intrathecal
7) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.74 Pain Relevance 1.08
There is also evidence that in neuropathic pain caused by nerve crush, ephrin-B2 expression is enhanced with similar consequences for synaptic signaling [10].
Gene_expression (expression) of ephrin-B2 in nerve associated with neuropathic pain
8) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.12 Pain Relevance 1.01
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain

Background

Gene_expression (expressed) of ephrin-B2 in Nociceptor associated with inflammation, nociceptor and neuropathic pain
9) Confidence 0.59 Published 2010 Journal Mol Pain Section Title Doc Link PMC2992507 Disease Relevance 1.33 Pain Relevance 1.06
In other cell types, for example bone, the induction of ephrin-B2 expression through the activation of transcription factor NFAT has been documented [33].
Gene_expression (expression) of ephrin-B2
10) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.88 Pain Relevance 0.86
The mechanism underlying the enhanced signaling mediated by ephrin-B2 in inflammation and tissue injury is likely to reflect increased ephrin-B2 protein expression in sensitized pain states.
Gene_expression (expression) of ephrin-B2 protein associated with pain, inflammation and injury
11) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.82 Pain Relevance 0.81
Interestingly, the recruitment of activated microglia, considered an important element in the induction of neuropathic pain was lowered at seven days post-injury, suggesting that signals from ephrin-B2 expressing nociceptors mediated by dorsal horn neurons result in some form of recruitment of activated microglia within the spinal cord.
Gene_expression (expressing) of ephrin-B2 in neurons associated with nociceptor, injury, neuropathic pain, dorsal horn neuron and spinal cord
12) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.20 Pain Relevance 1.18
Many inflammatory mediators - for example bradykinin - are also known to induce NFAT expression, so it is likely that enhanced expression of ephrin-B2 results in NMDA receptor NR2B phosphorylation that potentiates synaptic efficacy and increase calcium flux.
Gene_expression (expression) of ephrin-B2 associated with inflammatory mediators, nmda receptor and bradykinin
13) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.05 Pain Relevance 1.01
The exclusive pre-synaptic localization of the ephrin-B2 deletion avoids this ambiguity.
Gene_expression (deletion) of ephrin-B2
14) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.47 Pain Relevance 0.53
Presynaptic ephrin-B2 expression thus plays an important role in regulating inflammatory pain through the regulation of synaptic plasticity in the dorsal horn and is also involved in the pathogenesis of some types of neuropathic pain.



Gene_expression (expression) of ephrin-B2 in dorsal horn associated with eae, neuropathic pain and dorsal horn
15) Confidence 0.52 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2992507 Disease Relevance 1.60 Pain Relevance 1.36
Kobayashi et al, who showed ephrin-B2 expression up-regulation in DRG and spinal cord neurons in a model of neuropathic pain (spinal nerve ligation), prevented the development of mechanical allodynia with the intrathecal infusion of ephrin-B2 silencing RNAs [10].
Gene_expression (expression) of ephrin-B2 in spinal cord neurons associated with allodynia, eae, neuropathic pain, intrathecal and spinal cord
16) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.98 Pain Relevance 1.12
In order to identify the factors that are associated with cancer-induced pain, we first examined the expression of several genes involved in the ephrin signalling pathway, including ephrin A1, ephrin A2, ephrin B1, ephrin B2, and the Eph A1 and Eph B1 receptors, in the DRGs of six-week old C57BL/6 mice injected with B16/BL6 melanoma cells into the plantar region of the right hind paw.
Spec (examined) Gene_expression (expression) of ephrin B2 in paw associated with pain, cancer and skin cancer
17) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.68 Pain Relevance 1.21
In contrast, chronic morphine treatment causes significant upregulation of EphB receptor protein in mice spinal cord, while expression of ephrinBs (ephrinB1, ephrinB2, and PY99) remains unchanged [27].
Gene_expression (expression) of ephrinB2 in spinal cord associated with spinal cord and morphine
18) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.07 Pain Relevance 1.08
Glial cells at the optic chiasm express EphrinB2, an EphB1 ligand, and the interaction of these two membrane proteins mediates the axonal repulsive response of ipsilateral axons at the midline (Williams et al, 2003).
Gene_expression (express) of EphrinB2 in Glial cells
19) Confidence 0.02 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox