INT256285

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 32
Total Number 36
Disease Relevance 36.25
Pain Relevance 24.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb1) nucleus (Efnb1) cytoplasm (Efnb1)
Anatomy Link Frequency
spinal cord 6
paw 5
stromal cell 2
neuronal 1
Efnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
B1 receptor 243 100.00 Very High Very High Very High
Pain 2105 99.96 Very High Very High Very High
nMDA receptor 99 99.92 Very High Very High Very High
Spinal cord 247 99.84 Very High Very High Very High
Opioid 352 99.50 Very High Very High Very High
antagonist 135 99.00 Very High Very High Very High
Sciatic nerve 44 98.52 Very High Very High Very High
Morphine 96 98.10 Very High Very High Very High
allodynia 90 97.72 Very High Very High Very High
Eae 18 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 2192 99.96 Very High Very High Very High
Cancer 2057 99.76 Very High Very High Very High
Pancreatic Cancer 459 99.44 Very High Very High Very High
Neuropathic Pain 317 97.72 Very High Very High Very High
INFLAMMATION 334 97.04 Very High Very High Very High
Injury 11 96.84 Very High Very High Very High
Skin Cancer 216 95.56 Very High Very High Very High
Polydactyly 2 95.36 Very High Very High Very High
Morphine Dependence 27 92.96 High High
Congenital Anomalies 5 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
injection into the right hind paw on the gene expression of ephrin B1
Gene_expression (expression) of ephrin B1 in paw
1) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.19 Pain Relevance 0.49
production in cancer-inoculated regions, which in turn inhibits ephrin B1 gene expression, and tyrosine phosphorylation of NR2B.
Gene_expression (expression) of ephrin B1 associated with cancer
2) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.64 Pain Relevance 1.12
protein in cancer-inoculated regions, and significantly suppressed the gene expression of ephrin B1 in DRGs to a similar degree as Z-360.
Gene_expression (expression) of ephrin B1 associated with cancer
3) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.45 Pain Relevance 1.05
production from cancer-inoculated regions induces the gene expression of ephrin B1 in DRGs, which then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord, finally leading to pain.
Gene_expression (expression) of ephrin B1 in spinal cord associated with pain, cancer and spinal cord
4) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.41 Pain Relevance 0.86
induced the gene expression of ephrin B1 in L4-5 DRGs, we injected IL-1?
Gene_expression (expression) of ephrin B1
5) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.10 Pain Relevance 0.48
The repeated administration of devazepide significantly suppressed the expression of the ephrin B1 gene compared with the vehicle-treated group in cancer-induced pain mice (p < 0.01) (Figure 6A); however, the gene expression of the Eph B1 receptor was unchanged in all of the test groups (Figure 6B).
Gene_expression (expression) of ephrin B1 associated with pain, cancer and b1 receptor
6) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.90 Pain Relevance 0.49
(300 and 1000 pg/paw) directly into the plantar region of the right hind paw of eight-week old C57BL/6 mice, and examined the expression of the ephrin B1 and Eph B1 receptor genes in L4-5 DRGs after 60 min.
Spec (examined) Gene_expression (expression) of ephrin B1 in paw associated with b1 receptor
7) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.95 Pain Relevance 0.45
Among the factors highly expressed by PA6 cells, and known to be associated with CNS development, were stromal cell-derived factor 1 (SDF-1/CXCL12), pleiotrophin (PTN), insulin-like growth factor 2 (IGF2), and ephrin B1 (EFNB1).
Gene_expression (expressed) of EFNB1 in stromal cell
8) Confidence 0.55 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.11
Expression of ephrin B1 receptors EPHB2 and EPHB4 was also detected in undifferentiated hESC.
Gene_expression (Expression) of ephrin B1
9) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13
Effects of devazepide on ephrin B1 gene expression and IL-1?
Gene_expression (expression) of ephrin B1
10) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.93 Pain Relevance 0.49
Ephrin B1 gene expression in DRGs was induced in a cancer-induced pain model in mice
Gene_expression (expression) of Ephrin B1 associated with pain and cancer
11) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.68 Pain Relevance 1.25
Here, we examined the effects of devazepide on ephrin B1 gene expression in DRGs and the level of IL-1?
Gene_expression (expression) of ephrin B1
12) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.89 Pain Relevance 0.54
Moreover, we observed that the CCK1 receptor antagonist devazepide similarly suppressed up-regulation of ephrin B1 gene expression and IL-1?
Gene_expression (expression) of ephrin B1 associated with antagonist
13) Confidence 0.54 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.32 Pain Relevance 1.03
at 300 pg/paw had no effect on either ephrin B1 or Eph B1 receptor gene expression.


Gene_expression (expression) of ephrin B1 in paw associated with b1 receptor
14) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.88 Pain Relevance 0.49
from a cancer-inoculated region, induction of ephrin B1 gene expression in DRGs, and subsequent enhancement of tyrosine phosphorylation of NR2B in the spinal cord.
Gene_expression (expression) of ephrin B1 in spinal cord associated with cancer and spinal cord
15) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.61 Pain Relevance 1.31
To investigate the effects of increased gene expression of ephrin B1 in the mouse model of cancer-induced pain, we examined the change in the inflammatory mediator IL-1?
Gene_expression (expression) of ephrin B1 associated with pain, inflammation and cancer
16) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.52 Pain Relevance 0.70
injection (1000 pg/paw) into the plantar region of the right hind paw significantly induced the gene expression of ephrin B1 in L4-5 DRGs (p < 0.05), but not the Eph B1 receptor (Figure 5A, B).
Gene_expression (expression) of ephrin B1 in paw associated with b1 receptor
17) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.96 Pain Relevance 0.49
Z-360 treatment inhibited both ephrin B1 gene expression and the phosphorylation of NR2B.
Gene_expression (expression) of ephrin B1
18) Confidence 0.54 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.15 Pain Relevance 0.91
increased in cancer-inoculated regions and induced the expression of the ephrin B1 gene in the periphery of DRGs.
Gene_expression (expression) of ephrin B1 associated with cancer
19) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 2.21 Pain Relevance 1.53
As determined by quantitative real-time RT-PCR, the gene expression of ephrin B1 in lumbar (L) 4-5 DRGs was induced 1.8 fold in cancer-induced pain mice compared to normal control mice on day 15 after melanoma transplantation (p < 0.001) (Figure 1A); however, no change was observed for the Eph B1 receptor (Figure 1B).
Gene_expression (expression) of ephrin B1 associated with pain, cancer, b1 receptor and skin cancer
20) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.48 Pain Relevance 0.92

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