INT256286

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.36
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
neuron 4
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
hyperexcitability 36 99.48 Very High Very High Very High
Dorsal horn 33 96.76 Very High Very High Very High
Morphine 123 90.08 High High
Spinal cord 6 87.68 High High
Hyperalgesia 66 87.40 High High
Lasting pain 6 85.76 High High
addiction 114 81.92 Quite High
Thermal hyperalgesia 60 81.44 Quite High
Action potential 27 70.64 Quite High
Neurotransmitter 6 70.44 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 78 99.32 Very High Very High Very High
Hypersensitivity 12 94.48 High High
Nociception 6 91.44 High High
Hyperalgesia 126 87.40 High High
Neuropathic Pain 126 86.88 High High
Pain 30 85.76 High High
Morphine Dependence 81 81.92 Quite High
Injury 18 78.32 Quite High
Opiate Addiction 33 59.68 Quite High
Drug Dependence 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If so, loss of postsynaptic EphB1 receptor in the EphB1-/- mice may result in loss of reverse signaling and therefore the subsequent activities.
Negative_regulation (loss) of Gene_expression (receptor) of EphB1
1) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.30 Pain Relevance 1.22
Nerve injury-induced DRG neuron hyperexcitability are prevented or largely diminished in EphB1-/- and EphB1+/- mice
Negative_regulation (diminished) of Gene_expression (/) of EphB1 in neuron associated with nervous system injury and hyperexcitability
2) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.03 Pain Relevance 0.78
Nerve injury-induced DRG neuron hyperexcitability are prevented or largely diminished in EphB1-/- and EphB1+/- mice
Negative_regulation (diminished) of Gene_expression (/) of EphB1 in neuron associated with nervous system injury and hyperexcitability
3) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.03 Pain Relevance 0.78

General Comments

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