INT256298

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) mitochondrion (Creb1) DNA binding (Creb1)
cytoplasm (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
Creb1 (Mus musculus)
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 10 100.00 Very High Very High Very High
addiction 38 99.76 Very High Very High Very High
Morphine 41 99.32 Very High Very High Very High
Hyperalgesia 22 96.96 Very High Very High Very High
withdrawal 21 90.08 High High
Spinal cord 2 78.28 Quite High
hyperexcitability 12 71.28 Quite High
Dorsal horn 11 64.88 Quite High
Lasting pain 2 57.28 Quite High
Physical dependence 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Morphine Dependence 27 99.76 Very High Very High Very High
Hyperalgesia 42 96.96 Very High Very High Very High
Neuropathic Pain 42 96.44 Very High Very High Very High
Nervous System Injury 26 69.36 Quite High
Nociception 2 60.32 Quite High
Pain 10 57.28 Quite High
Drug Dependence 4 50.00 Quite Low
Opiate Addiction 11 27.80 Quite Low
Targeted Disruption 10 16.00 Low Low
Ganglion Cysts 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EphB1 receptor may act by interaction with the NR2B subtype of NMDA receptors [27] and then activate the postsynaptic signals ERKs [27,64] and CREB [27,65,66], or NO pathways [46,67], while the ephrinBs do not seem to be necessary in this process.
CREB Binding (interaction) of EphB1 associated with nmda receptor
1) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.27 Pain Relevance 1.22

General Comments

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