INT256299

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.22
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Efnb1, Ephb1) endosome (Ephb1) cell differentiation (Efnb1)
signal transduction (Ephb1) cell adhesion (Ephb1) plasma membrane (Ephb1)
Efnb1 (Mus musculus)
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 22 98.24 Very High Very High Very High
addiction 38 95.92 Very High Very High Very High
Morphine 41 95.48 Very High Very High Very High
Neuropathic pain 29 82.96 Quite High
opiate 15 78.48 Quite High
nMDA receptor 10 75.84 Quite High
opioid receptor 8 63.08 Quite High
Dorsal horn 11 61.32 Quite High
Pain 7 59.04 Quite High
Neurotransmitter 2 56.96 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 42 98.24 Very High Very High Very High
Morphine Dependence 27 95.92 Very High Very High Very High
Neuropathic Pain 42 82.96 Quite High
Opiate Addiction 11 78.48 Quite High
Nervous System Injury 26 67.60 Quite High
Pain 10 59.04 Quite High
Drug Dependence 4 50.00 Quite Low
Targeted Disruption 10 29.12 Quite Low
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study further shows that binding to the EphB1 receptor is required for ephrinBs such as ephrinB1-Fc, which may also bind to EphB1-4 and EphA4 receptors, to promote behavioral hyperalgesia and that the EphB1 receptor protein-null mutant mice fail to development hyperalgesia or morphine dependence.
ephrinB1 Binding (bind) of EphB1-4 associated with addiction, hyperalgesia and morphine
1) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.22 Pain Relevance 1.42

General Comments

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