INT25634

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 14.78
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
polymorphonuclear leukocytes 3
macrophages 2
MPO 2
plasma 1
brain 1
Mpo (Rattus norvegicus)
Mpo - G463A (1)
Pain Link Frequency Relevance Heat
cytokine 41 100.00 Very High Very High Very High
Raphe magnus 24 100.00 Very High Very High Very High
Paracetamol 14 99.98 Very High Very High Very High
Inflammation 117 99.92 Very High Very High Very High
Inflammatory mediators 4 99.90 Very High Very High Very High
Angina 9 99.62 Very High Very High Very High
Central grey 16 98.00 Very High Very High Very High
lidocaine 1 97.20 Very High Very High Very High
cva 62 96.84 Very High Very High Very High
fibrosis 52 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 190 100.00 Very High Very High Very High
Myocardial Infarction 26 100.00 Very High Very High Very High
INFLAMMATION 159 99.92 Very High Very High Very High
Renal Disease 6 99.92 Very High Very High Very High
Angina 6 99.62 Very High Very High Very High
Acute Coronary Syndrome 5 99.44 Very High Very High Very High
Interstitial Lung Diseases 2 97.76 Very High Very High Very High
Cv General 3 Under Development 19 96.84 Very High Very High Very High
Alveolar Bone Loss 7 96.28 Very High Very High Very High
Pulmonary Fibrosis 46 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we tested the hypothesis that levels of MPO in plasma after a myocardial infarction are affected by its ability to bind to the endothelium and there is local release of the enzyme at the culprit lesion.
MPO Binding (bind) of in plasma associated with urological neuroanatomy and myocardial infarction
1) Confidence 0.48 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20643239 Disease Relevance 0.84 Pain Relevance 0.06
Myeloperoxidase (MPO) is associated with risk in acute coronary syndromes.
Myeloperoxidase Binding (associated) of associated with acute coronary syndrome and urological neuroanatomy
2) Confidence 0.48 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20643239 Disease Relevance 0.66 Pain Relevance 0
Myeloperoxidase (MPO) is associated with risk in acute coronary syndromes.
MPO Binding (associated) of associated with acute coronary syndrome and urological neuroanatomy
3) Confidence 0.48 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20643239 Disease Relevance 0.66 Pain Relevance 0
The interaction of myeloperoxidase (MPO) with H2O2 and Cl- provides a potent antimicrobial/cytotoxic system for polymorphonuclear leukocytes (PMNs).
myeloperoxidase Binding (interaction) of in polymorphonuclear leukocytes associated with urological neuroanatomy
4) Confidence 0.46 Published 1982 Journal Agents Actions Section Abstract Doc Link 6282074 Disease Relevance 0.57 Pain Relevance 0.22
The interaction of myeloperoxidase (MPO) with H2O2 and Cl- provides a potent antimicrobial/cytotoxic system for polymorphonuclear leukocytes (PMNs).
MPO Binding (interaction) of in polymorphonuclear leukocytes associated with urological neuroanatomy
5) Confidence 0.46 Published 1982 Journal Agents Actions Section Abstract Doc Link 6282074 Disease Relevance 0.57 Pain Relevance 0.28
Cyclosporin A reduced MPO activity, and 5-aminosalicylic acid reduced the colonic damage score, whereas lidocaine and two inhibitors of leukotriene synthesis did not significantly affect either of these parameters.
MPO Binding (activity) of associated with urological neuroanatomy and lidocaine
6) Confidence 0.37 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7631788 Disease Relevance 1.13 Pain Relevance 0.29
It is concluded that: (1) in response to chemical stimulation of MPO, the number of I-cells that were inhibited was more than three times the number of I-cells that were excited; in contrast, the number of E-cells that were excited was more than twice the number of E-cells that were inhibited. (2) The interaction between MPO and NRM can be modulated by blockade of the neuronal transmission or blockade of the glutamatergic system in the PAG. (3) Simultaneous activity of many synapses is required for activation of the MPO-NRM pathway. (4) MPO to NRM interaction is mediated by fibers with a conduction velocity of less than 1m/s.
MPO Binding (interaction) of in MPO associated with raphe magnus, urological neuroanatomy and central grey
7) Confidence 0.37 Published 2001 Journal Pain Section Abstract Doc Link 11690727 Disease Relevance 0.92 Pain Relevance 0.45
Myeloperoxidase activity
Myeloperoxidase Binding (activity) of
8) Confidence 0.36 Published 2010 Journal Thromb J Section Body Doc Link PMC2843658 Disease Relevance 0.32 Pain Relevance 0
However, MPO was not useful for the diagnosis of myocardial infarction (c-statistics 0.61 [95% CI 0.54-0.67]), and Cox regression analysis revealed no independent association between MPO and mortality (adjusted hazard ratio 1.3 [95% CI 0.8-2.0]) or the composite endpoint (adjusted hazard ratio 1.1 [95% CI 0.8-1.5]) after a median follow-up of 4.9 years.
MPO Binding (association) of
9) Confidence 0.36 Published 2010 Journal Clin. Biochem. Section Body Doc Link 19822136 Disease Relevance 0.08 Pain Relevance 0
LDL, treated with myeloperoxidase, hydrogen peroxide and nitrite for 14 h, was metabolized by macrophages to a much greater extent than native LDL.
myeloperoxidase Binding (metabolized) of in macrophages
10) Confidence 0.35 Published 2002 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11960752 Disease Relevance 0 Pain Relevance 0.63
Serial blood samples taken between 1 and 24 h after the onset of chest pain were analyzed for MPO, TnT, creatine kinase MB, myoglobin, and high sensitive C-reactive protein.
MPO Spec (analyzed) Binding (myoglobin) of in chest associated with angina and urological neuroanatomy
11) Confidence 0.34 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19362143 Disease Relevance 1.87 Pain Relevance 0.10
EP decreases production of inflammatory mediators and MPO activity
MPO Binding (activity) of associated with inflammatory mediators and urological neuroanatomy
12) Confidence 0.34 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2995973 Disease Relevance 0.43 Pain Relevance 0.18
In conclusion, EP inhibited MPO activity, inflammatory cytokine release, and NF-?
MPO Binding (activity) of associated with inflammation, urological neuroanatomy and cytokine
13) Confidence 0.34 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2995973 Disease Relevance 0.97 Pain Relevance 0.33
It is concluded that: (1) in response to chemical stimulation of MPO, the number of I-cells that were inhibited was more than three times the number of I-cells that were excited; in contrast, the number of E-cells that were excited was more than twice the number of E-cells that were inhibited. (2) The interaction between MPO and NRM can be modulated by blockade of the neuronal transmission or blockade of the glutamatergic system in the PAG. (3) Simultaneous activity of many synapses is required for activation of the MPO-NRM pathway. (4) MPO to NRM interaction is mediated by fibers with a conduction velocity of less than 1m/s.
MPO Binding (interaction) of in MPO associated with raphe magnus, urological neuroanatomy and central grey
14) Confidence 0.32 Published 2001 Journal Pain Section Abstract Doc Link 11690727 Disease Relevance 0.88 Pain Relevance 0.44
Myeloperoxidase activity
Myeloperoxidase Binding (activity) of
15) Confidence 0.32 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.28 Pain Relevance 0
The second is that ANCA antigens such as MPO undergo translocation to the surface of neutrophils (possibly in response to proinflammatory cytokines), and subsequent binding of circulating ANCA results in neutrophil degranulation and the release of reactive oxygen species, causing injury and consequent fibrosis [5,6].
MPO Binding (binding) of in neutrophil associated with fibrosis, injury, urological neuroanatomy and cytokine
16) Confidence 0.31 Published 2010 Journal NDT Plus Section Body Doc Link PMC2904803 Disease Relevance 2.04 Pain Relevance 0.54
In one Japanese study of patients presenting with glomerulonephritis in association with anti-MPO antibodies, 27 out of 40 had evidence of non-infective interstitial pneumonitis, with coexisting pulmonary haemorrhage in 7 [2].
anti-MPO Binding (association) of associated with interstitial lung diseases, renal disease, urological neuroanatomy and cva
17) Confidence 0.31 Published 2010 Journal NDT Plus Section Body Doc Link PMC2904803 Disease Relevance 1.84 Pain Relevance 0.32
RESULTS: The variant A allele of MPO -G463A was associated with a lower risk of pancreatic cancer (adjusted odds ratio [OR] for pancreatic cancer, 0.57; 95% confidence interval [95% CI], 0.4-0.9; P = .02).
MPO (G463A) Binding (associated) of
18) Confidence 0.30 Published 2008 Journal Cancer Section Body Doc Link 18205184 Disease Relevance 0 Pain Relevance 0
Acetaminophen binds via its acetamido side chain to purified myeloperoxidase in a pH-dependent manner and maximum binding occurred around pH 6.
myeloperoxidase Binding (binds) of associated with paracetamol
19) Confidence 0.25 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2535934 Disease Relevance 0 Pain Relevance 0.39
Myeloperoxidase activity
Myeloperoxidase Binding (activity) of
20) Confidence 0.19 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.17 Pain Relevance 0

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