INT256345

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 26
Disease Relevance 9.51
Pain Relevance 6.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
nucleus 3
astrocytes 2
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 546 99.36 Very High Very High Very High
cytokine 476 98.88 Very High Very High Very High
Inflammation 343 97.96 Very High Very High Very High
opiate 126 95.20 Very High Very High Very High
chemokine 95 92.80 High High
agonist 14 91.32 High High
dorsal root ganglion 3 89.76 High High
ischemia 62 83.96 Quite High
Inflammatory mediators 12 78.52 Quite High
Peripheral nervous system 2 61.52 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 366 99.84 Very High Very High Very High
Injury 93 98.48 Very High Very High Very High
INFLAMMATION 344 97.96 Very High Very High Very High
Hemorrhagic Shock 92 96.88 Very High Very High Very High
Cancer 268 95.60 Very High Very High Very High
Apoptosis 361 95.40 Very High Very High Very High
Necrosis 28 95.12 Very High Very High Very High
Stress 58 93.76 High High
Shock 32 93.52 High High
Ganglion Cysts 13 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional upregulation of the p65 (RelA) subunit of NF-?
Phosphorylation (subunit) of RelA
1) Confidence 0.75 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.53 Pain Relevance 0.21
Transcriptional upregulation of the p65 (RelA) subunit of NF-?
Phosphorylation (subunit) of p65
2) Confidence 0.75 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.53 Pain Relevance 0.21
Thus, we propose that combined Tat and morphine cause a sustained cytokine expression/release in astrocytes through the sustained phosphorylation of p65 (RelA) and enhanced nucleocytoplasmic shuttling of NF-?
Phosphorylation (phosphorylation) of RelA in astrocytes associated with cytokine and morphine
3) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.89
Thus, we propose that combined Tat and morphine cause a sustained cytokine expression/release in astrocytes through the sustained phosphorylation of p65 (RelA) and enhanced nucleocytoplasmic shuttling of NF-?
Phosphorylation (phosphorylation) of p65 in astrocytes associated with cytokine and morphine
4) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.89
Tat±morphine markedly increased the translocation of the p65 (RelA) subunit of NF-?
Phosphorylation (subunit) of RelA associated with morphine
5) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.78
Moreover, we found that buffering [Ca2+]i reduced the trafficking of the p65 (RelA) subunit of NF-?
Phosphorylation (subunit) of RelA
6) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.36
Tat±morphine markedly increased the translocation of the p65 (RelA) subunit of NF-?
Phosphorylation (subunit) of p65 associated with morphine
7) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.78
Moreover, we found that buffering [Ca2+]i reduced the trafficking of the p65 (RelA) subunit of NF-?
Phosphorylation (subunit) of p65
8) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.37
phosphorylation, the rate of p65 translocation into the nucleus, and NF-?
Phosphorylation (phosphorylation) of p65 in nucleus
9) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.25 Pain Relevance 0.98
Significantly, phosphorylation of the p65 subunit by PKA increases transcriptional activity but not DNA binding and is required for upregulation of Oct-6 by cAMP.
Phosphorylation (phosphorylation) of p65 subunit
10) Confidence 0.40 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.23 Pain Relevance 0.12
-induced p65 nuclear translocation and p65 phosphorylation in pancreatic cancer cells
Phosphorylation (phosphorylation) of p65 associated with pancreatic cancer
11) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.41 Pain Relevance 0
induced p65 nuclear translocation and p65 phosphorylation (Fig. 4B, right), suggesting that MA suppresses TNF?
Phosphorylation (phosphorylation) of p65
12) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.47 Pain Relevance 0
degradation, p65 phosphorylation and nuclear translocation, as well as NF-?
Phosphorylation (phosphorylation) of p65
13) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.46 Pain Relevance 0.07
degradation, p65 phosphorylation, and nuclear translocation.
Phosphorylation (phosphorylation) of p65
14) Confidence 0.28 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2907730 Disease Relevance 1.40 Pain Relevance 0.04
degradation, block p65 nuclear translocation and phosphorylation, and finally, down-regulate the expression levels of NF-?
Phosphorylation (phosphorylation) of p65
15) Confidence 0.28 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.22 Pain Relevance 0
induced p65 nuclear translocation and p65 phosphorylation (Fig. 4B, right), suggesting that MA suppresses TNF?
Phosphorylation (phosphorylation) of p65
16) Confidence 0.28 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.47 Pain Relevance 0
B may depend on the phosphorylation status of p65, and LXR receptor may play a central role in this process.
Phosphorylation (phosphorylation) of p65
17) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.36 Pain Relevance 0.34
B (p65) phosphorylation was attenuated by up-regulation of HO-1 in bEnd.3 cells.


Phosphorylation (phosphorylation) of p65
18) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.12 Pain Relevance 0.03
B (p65) phosphorylation was also inhibited by pretreatment with CoPP (0.3 ?
Phosphorylation (phosphorylation) of p65
19) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.14 Pain Relevance 0.03
B (p65) phosphorylation
Phosphorylation (phosphorylation) of p65
20) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.19 Pain Relevance 0.05

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