INT256357

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rela, Ik) cytosol (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
astrocytes 3
Rela (Mus musculus)
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 63 100.00 Very High Very High Very High
Morphine 78 99.62 Very High Very High Very High
chemokine 11 40.96 Quite Low
opiate 18 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
opioid receptor 6 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 51.88 Quite High
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Viral Meningitis 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Opportunistic Infections 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we propose that combined Tat and morphine cause a sustained cytokine expression/release in astrocytes through the sustained phosphorylation of p65 (RelA) and enhanced nucleocytoplasmic shuttling of NF-?
Phosphorylation (phosphorylation) of p65 in astrocytes Positive_regulation (through) of Localization (release) of cytokine in astrocytes associated with cytokine and morphine
1) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.05 Pain Relevance 0.96

General Comments

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