INT25646

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Context Info
Confidence 0.08
First Reported 1986
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.08
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRLR) plasma membrane (PRLR)
Anatomy Link Frequency
tail 1
brain 1
PRLR (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 8 98.56 Very High Very High Very High
tail-flick 4 98.52 Very High Very High Very High
agonist 8 98.44 Very High Very High Very High
Potency 10 97.92 Very High Very High Very High
Endogenous opioid 1 96.40 Very High Very High Very High
opioid receptor 10 92.56 High High
Enkephalin 6 91.12 High High
withdrawal 2 80.32 Quite High
Physical dependence 1 75.12 Quite High
MU agonist 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, the present findings indicate that delta receptor down-regulation in vivo may be an important mechanism in the adaptive response to chronic exposure to an endogenous opioid peptide.
Negative_regulation (down-regulation) of delta receptor associated with endogenous opioid
1) Confidence 0.08 Published 1986 Journal Brain Res. Bull. Section Abstract Doc Link 3021290 Disease Relevance 0.08 Pain Relevance 0.53
All the analogues showed diminished delta-receptor selectivity in the rat brain binding assay.
Negative_regulation (diminished) of delta-receptor in brain
2) Confidence 0.02 Published 1989 Journal J. Med. Chem. Section Abstract Doc Link 2536436 Disease Relevance 0 Pain Relevance 0.15
The results showed: (1) the level of delta receptor mRNA decreased significantly 24-48 h after administration of DPDPE; the effect of BW373U86 lasted only 24 h; and (2) DPDPE produced a significant decrease of delta-receptor mRNA at 10(-6) mol/L, whereas BW373U86 was effective only at 10(-5) mol/L.
Negative_regulation (decreased) of delta receptor
3) Confidence 0.00 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324539 Disease Relevance 0 Pain Relevance 0.54
Replacement of Tyr1 in deltorphin I with Phe produced a 32-fold decrease in delta receptor affinity but only a 7-fold drop in antinociceptive potency.
Negative_regulation (decrease) of delta receptor associated with antinociceptive and potency
4) Confidence 0.00 Published 1997 Journal Peptides Section Abstract Doc Link 9437724 Disease Relevance 0 Pain Relevance 0.67
The D- and L-Pro2-, Sar2- and D-Tle2-analogs showed much reduced delta receptor affinities and were inactive in the tail flick test.
Negative_regulation (reduced) of delta receptor in tail associated with tail-flick
5) Confidence 0.00 Published 1997 Journal Peptides Section Abstract Doc Link 9437724 Disease Relevance 0 Pain Relevance 0.74

General Comments

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