INT25647

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.47
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
spinal cord 3
hypothalamus 2
ventral 2
pits 2
brain 1
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 3 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
pregabalin 13 99.74 Very High Very High Very High
Morphine 2 99.72 Very High Very High Very High
opioid receptor 13 99.64 Very High Very High Very High
midbrain 2 99.58 Very High Very High Very High
opiate 9 99.52 Very High Very High Very High
Immobilon 6 99.52 Very High Very High Very High
MU agonist 2 99.38 Very High Very High Very High
Hippocampus 1 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 6 99.64 Very High Very High Very High
Neuropathic Pain 1 98.64 Very High Very High Very High
Neuroblastoma 1 92.84 High High
Pain 4 85.04 High High
Post Operative Pain 4 75.00 Quite High
Anxiety Disorder 2 75.00 Quite High
Dementia 2 71.60 Quite High
Cognitive Disorder 1 55.84 Quite High
Lordosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In standard 3H-opioid binding assays, the benzoylhydrazone derivative of naloxone (6-desoxy-6-benzoylhydrazido-N-allyl-14-hydroxydihydronormorphi none; NalBzoH) inhibited mu, kappa, and delta binding at nanomolar concentrations.
Negative_regulation (inhibited) of delta Binding (binding) of associated with narcan and opioid
1) Confidence 0.57 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2536470 Disease Relevance 0 Pain Relevance 0.38
Binding of delta-opioid receptors is also decreased in the amygdaloid complex and ventral putamen of Alzheimer's disease brains.
Negative_regulation (decreased) of delta Binding (Binding) of in ventral associated with delta opioid receptors and disease
2) Confidence 0.57 Published 2001 Journal Brain Res. Section Abstract Doc Link 11223000 Disease Relevance 0.61 Pain Relevance 0.73
These data reveal the operation of a homologous regulation mechanism that rapidly diminishes the interaction of delta-subtype opioid receptors with peptide ligands but does not detectably change the interaction of receptors with alkaloid ligands.
Negative_regulation (diminishes) of delta Binding (interaction) of associated with opioid receptor
3) Confidence 0.57 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8393518 Disease Relevance 0 Pain Relevance 1.07
The mu agonists such as morphine and fentanyl display a very low affinity for delta and kappa receptor.
Negative_regulation (display) of delta Binding (affinity) of associated with mu agonist and morphine
4) Confidence 0.42 Published 1995 Journal Masui Section Abstract Doc Link 8523655 Disease Relevance 0 Pain Relevance 0.97
BACKGROUND: Pregabalin inhibits release of excess excitatory neurotransmitters, presumably by binding to the alpha2-delta subunit protein of widely distributed voltage-dependent calcium channels in the brain and spinal cord.
Negative_regulation (inhibits) of delta in brain Binding (binding) of in spinal cord associated with pregabalin, neurotransmitter, calcium channel and spinal cord
5) Confidence 0.41 Published 2005 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 16143734 Disease Relevance 0.07 Pain Relevance 0.40
The rapid internalization of delta receptors is specifically inhibited in cells expressing K44E mutant dynamin I, suggesting that type-specific internalization of opioid receptors is mediated by clathrin-coated pits.
Negative_regulation (inhibited) of delta Binding (internalization) of in pits associated with opioid receptor
6) Confidence 0.41 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341153 Disease Relevance 0 Pain Relevance 0.60
The lesion decreased mu-receptor binding in the preoptic area (mPOA) and the midbrain central gray, while delta-receptor binding was decreased in the mPOA and the dorsomedial nucleus of the hypothalamus.
Negative_regulation (decreased) of delta Binding (binding) of in hypothalamus associated with midbrain
7) Confidence 0.41 Published 1993 Journal Brain Res. Section Abstract Doc Link 8275308 Disease Relevance 0 Pain Relevance 0.43
TM treatment reduced ligand binding at delta- and sigma-opiate receptors and neuroleptic binding sites (20 to 50% of control), with no discernible effect on the binding properties of 5HT1-serotonin receptors.
Negative_regulation (reduced) of delta Binding (binding) of associated with opiate and serotonin
8) Confidence 0.41 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3004490 Disease Relevance 0.09 Pain Relevance 0.35
Pregabalin is thought to act by reducing the excessive release of several excitatory neurotransmitters by binding to the alpha(2)-delta protein subunit of voltage-gated calcium channels.
Negative_regulation (reducing) of delta Binding (binding) of associated with pregabalin, neurotransmitter and calcium channel
9) Confidence 0.41 Published 2009 Journal Drugs Aging Section Abstract Doc Link 19761281 Disease Relevance 0.62 Pain Relevance 1.45
BACKGROUND: Pregabalin inhibits release of excess excitatory neurotransmitters, presumably by binding to the alpha2-delta subunit protein of widely distributed voltage-dependent calcium channels in the brain and spinal cord.
Negative_regulation (inhibits) of delta Binding (binding) of in spinal cord associated with pregabalin, neurotransmitter, calcium channel and spinal cord
10) Confidence 0.14 Published 2005 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 16143734 Disease Relevance 0.07 Pain Relevance 0.40

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