INT256476

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ces1c) endoplasmic reticulum (Ces1c)
Anatomy Link Frequency
spermatozoa 2
Ces1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 91.48 High High
Congenital Anomalies 6 57.68 Quite High
Sperm Disorder 8 54.48 Quite High
Death 4 5.00 Very Low Very Low Very Low
Male Infertility 4 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Emergencies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We were therefore keen to examine the fertilizing capacity of spermatozoa from rats in which HongrES1 gene expression was knocked down and evaluate the effect of accelerated capacitation that takes place when the apparent inhibitory action of this protein was blocked.
Negative_regulation (knocked) of Gene_expression (expression) of HongrES1 in spermatozoa
1) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.20 Pain Relevance 0
Figure 4A shows that both siRNAs could inhibit HongrES1 expression almost completely at the mRNA and protein levels at 48 h after transfection.
Negative_regulation (inhibit) of Gene_expression (expression) of HongrES1
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.19 Pain Relevance 0

General Comments

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