INT256540

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.74
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
Anatomy Link Frequency
hepatocytes 2
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 82 84.80 Quite High
agonist 23 77.08 Quite High
Inflammatory response 3 54.24 Quite High
COX2 22 49.44 Quite Low
cOX1 1 36.16 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 371 100.00 Very High Very High Very High
Apoptosis 60 98.84 Very High Very High Very High
INFLAMMATION 85 93.92 High High
Repression 4 91.88 High High
Colon Cancer 18 90.96 High High
Lymphatic System Cancer 25 82.76 Quite High
Disease 36 79.88 Quite High
Chronic Disease 4 63.92 Quite High
Aging 2 58.40 Quite High
Death 9 51.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various regulatory factors control the expression of genes such as tumor suppressor genes and oncogenes, allowing for the timely and coordinated execution of these processes.
Regulation (control) of Gene_expression (expression) of tumor suppressor associated with cancer
1) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.28 Pain Relevance 0
Conversely, increased expression of tumor suppressor miRNAs would most likely affect cellular processes in a similar manner, adding to the anti-cancer effects of these agents.
Regulation (affect) of Gene_expression (expression) of tumor suppressor associated with cancer
2) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.97 Pain Relevance 0
Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and activities of transcriptional factors involved in both cancer initiation and progression through alteration of either DNA or the structural components of chromatin.

Regulation (regulate) of Gene_expression (expression) of tumor suppressor associated with cancer
3) Confidence 0.01 Published 2010 Journal J Hematol Oncol Section Title Doc Link PMC2827364 Disease Relevance 0.86 Pain Relevance 0
regulates the expression of miRNA let-7C in hepatocytes, a tumor suppressor gene that regulates cancer cell proliferation.
Regulation (regulates) of Gene_expression (expression) of tumor suppressor in hepatocytes associated with cancer
4) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 1.62 Pain Relevance 0.30

General Comments

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