INT256544

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.07 Pain Relevance 0.11

enzyme binding (Pten, Akt1) cytoplasm (Pten, Akt1) nucleus (Pten, Akt1) plasma membrane (Pten, Akt1) phosphatase activity (Pten) transport (Akt1)

Anatomy Link Frequency thyroid 1 Pten (Mus musculus) Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 81 55.96 agonist 23 55.04 COX2 22 5.00 cytokine 8 5.00 fibrosis 4 5.00 Inflammatory response 3 5.00 psoriasis 3 5.00 Chronic pancreatitis 1 5.00 cINOD 1 5.00 Inflammatory marker 1 5.00

Disease Link Frequency Relevance Heat Thyroid Neoplasm 2 96.96 Apoptosis 11 93.96 Targeted Disruption 2 80.76 Skin Cancer 12 79.72 Cancer 76 78.24 Lung Cancer 4 61.64 INFLAMMATION 84 55.96 Hypersensitivity 1 53.32 Inflammatory Bowel Disease 14 5.00 Colon Cancer 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This was at least partially due to upregulation of PTEN and inhibition of Akt activity, which antagonized IGF-1 effects necessary for the progression of thyroid cancers [199].

PTEN Negative_regulation (inhibition) of Akt in thyroid associated with thyroid neoplasm

1) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 1.07 Pain Relevance 0.11

General Comments

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