INT256545

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Pten, Akt1) cytoplasm (Pten, Akt1) nucleus (Pten, Akt1)
plasma membrane (Pten, Akt1) phosphatase activity (Pten) transport (Akt1)
Anatomy Link Frequency
thyroid 2
Pten (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 81 56.60 Quite High
agonist 23 55.68 Quite High
COX2 22 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 2 96.96 Very High Very High Very High
Apoptosis 11 94.60 High High
Targeted Disruption 2 81.40 Quite High
Skin Cancer 12 80.36 Quite High
Cancer 76 78.24 Quite High
Lung Cancer 4 62.28 Quite High
INFLAMMATION 84 56.60 Quite High
Hypersensitivity 1 53.96 Quite High
Inflammatory Bowel Disease 14 5.00 Very Low Very Low Very Low
Colon Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was at least partially due to upregulation of PTEN and inhibition of Akt activity, which antagonized IGF-1 effects necessary for the progression of thyroid cancers [199].
Positive_regulation (upregulation) of PTEN Negative_regulation (inhibition) of Akt in thyroid associated with thyroid neoplasm
1) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 1.07 Pain Relevance 0.11

General Comments

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