INT256595

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Context Info
Confidence 0.62
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.87
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB103A)
Anatomy Link Frequency
skin 1
DEFB103A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 57 86.92 High High
Inflammation 42 78.96 Quite High
psoriasis 150 56.64 Quite High
rheumatoid arthritis 30 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 207 93.48 High High
INFLAMMATION 42 78.96 Quite High
Skin Diseases 15 72.64 Quite High
Eczema 57 57.52 Quite High
Disease 120 50.00 Quite Low
Infection 6 41.60 Quite Low
Viral Infection 3 34.64 Quite Low
Rheumatoid Arthritis 33 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 13 5.00 Very Low Very Low Very Low
Amyloidosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is located in HBP3, the other, fluorine at C-4?
Localization (located) of HBP3
1) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0 Pain Relevance 0
Anti-hBD-2 antibodies were checked for specificity against hBD-2, and we found that recombinant hBD-1 (Abcam) and hBD-3 (Abcam) were not recognized.
Neg (not) Localization (recognized) of hBD-3
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0 Pain Relevance 0
Of the eight beta-defensin genes located on 8p23.1, human beta-defensin-1 (hBD-1) protein, (encoded by DEFB1) and hBD-3 (encoded by DEFB103) are constitutively expressed at low levels in skin [24]. hBD-2 (encoded by DEFB4) is not expressed in normal skin but is highly expressed in psoriatic skin. hBD-4 (encoded by DEFB104) is less well characterized at the protein level but is found in skin by RT-PCR. hBD-2, hBD-3 and hBD-4 can be induced by cytokines and bacterial lipopolysaccharides in various epithelial cell types [25].
Localization (located) of hBD-3 in skin associated with psoriasis and cytokine
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.55 Pain Relevance 0.20
In addition, commercially available ELISA kits were used to measure hBD-2 and hBD-3 protein in serum.
Localization (measure) of hBD-3
4) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.32 Pain Relevance 0.04

General Comments

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