INT256598

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 5.06
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB103A)
Anatomy Link Frequency
skin 3
enterocytes 1
colon 1
DEFB103A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 165 99.00 Very High Very High Very High
psoriasis 303 98.68 Very High Very High Very High
Crohn's disease 66 91.84 High High
cytokine 123 91.44 High High
Inflammatory response 6 76.40 Quite High
Potency 21 67.24 Quite High
rheumatoid arthritis 60 67.04 Quite High
fibrosis 3 28.44 Quite Low
chemokine 15 19.84 Low Low
Bile 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 324 99.60 Very High Very High Very High
INFLAMMATION 153 99.00 Very High Very High Very High
Psoriasis 417 98.68 Very High Very High Very High
Infection 45 98.36 Very High Very High Very High
Esophageal Disease 3 94.04 High High
Skin Diseases 30 90.40 High High
Inflammatory Bowel Disease 60 88.08 High High
Neutropenia 3 87.56 High High
Helicobacter Infection 6 87.36 High High
Sprains And Strains 11 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-defensins are mainly produced by epithelial cells [9], and four subtypes, designated hBD-1 to hBD-4, have been identified in the human mucosa so far. hBD-1 is ubiquitously expressed at all surfaces of the human body including the skin, the respiratory, urogenital and the gastrointestinal tract [10–15]. hBD-2 and hBD-3 are inducible antimicrobial peptides expressed by enterocytes throughout the intestinal tract on demand.
Gene_expression (expressed) of hBD-3 in enterocytes
1) Confidence 0.65 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.05 Pain Relevance 0
-defensin expression (hBD-2 and hBD-3) could be found, although to a minor degree [31].

3.2.

Gene_expression (expression) of hBD-3
2) Confidence 0.58 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 1.03 Pain Relevance 0.07
In the healthy colon, hBD-2 and hBD-3 are absent and only induced during inflammation or infection.
Neg (absent) Gene_expression (absent) of hBD-3 in colon associated with inflammation and infection
3) Confidence 0.58 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.77 Pain Relevance 0.29
The innermost HBP pockets, HBP3 and HBP3?
Gene_expression (The) of HBP3
4) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0 Pain Relevance 0
The innermost HBP pockets, HBP3 and HBP3?
Gene_expression (The) of HBP3
5) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0 Pain Relevance 0
We show that both genetic factors and disease activity determine defensin protein expression.
Spec (determine) Gene_expression (expression) of defensin protein associated with disease
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.18 Pain Relevance 0.30
The detection limits for these assays were 0.05 and 0.1 ng/ml respectively, using synthetic hBD-2 and hBD-3 for calibration.


Gene_expression (synthetic) of hBD-3
7) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.18 Pain Relevance 0.05
Of the eight beta-defensin genes located on 8p23.1, human beta-defensin-1 (hBD-1) protein, (encoded by DEFB1) and hBD-3 (encoded by DEFB103) are constitutively expressed at low levels in skin [24]. hBD-2 (encoded by DEFB4) is not expressed in normal skin but is highly expressed in psoriatic skin. hBD-4 (encoded by DEFB104) is less well characterized at the protein level but is found in skin by RT-PCR. hBD-2, hBD-3 and hBD-4 can be induced by cytokines and bacterial lipopolysaccharides in various epithelial cell types [25].
Gene_expression (expressed) of DEFB103 in skin associated with psoriasis and cytokine
8) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.45 Pain Relevance 0.17
Psoriasis is associated with increased beta-defensin genomic copy number but no quantitative information on defensin protein expression in vivo, as a function of copy number or disease status was available.
Gene_expression (expression) of defensin protein associated with psoriasis and disease
9) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.41 Pain Relevance 0.25
Whether this also reflects low hBD-3 protein production in the epidermis requires further investigation.
Gene_expression (production) of hBD-3 in epidermis
10) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.53 Pain Relevance 0.20
Of the eight beta-defensin genes located on 8p23.1, human beta-defensin-1 (hBD-1) protein, (encoded by DEFB1) and hBD-3 (encoded by DEFB103) are constitutively expressed at low levels in skin [24]. hBD-2 (encoded by DEFB4) is not expressed in normal skin but is highly expressed in psoriatic skin. hBD-4 (encoded by DEFB104) is less well characterized at the protein level but is found in skin by RT-PCR. hBD-2, hBD-3 and hBD-4 can be induced by cytokines and bacterial lipopolysaccharides in various epithelial cell types [25].
Gene_expression (expressed) of hBD-3 in skin associated with psoriasis and cytokine
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.45 Pain Relevance 0.17

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