INT256628

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.12
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl)
Anatomy Link Frequency
enamels 1
hair 1
brain 1
midbrain 1
cerebellum 1
Nsdhl (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 24 98.44 Very High Very High Very High
Glutamate 12 89.28 High High
ketamine 12 88.08 High High
nMDA receptor antagonist 4 84.72 Quite High
Neuropeptide 4 78.88 Quite High
Locus ceruleus 40 74.48 Quite High
Dopamine 140 74.40 Quite High
depression 4 23.88 Low Low
cytokine 8 23.20 Low Low
gABA 64 22.72 Low Low
Disease Link Frequency Relevance Heat
Basal Cell Nevus Syndrome 88 99.84 Very High Very High Very High
Disease 115 99.12 Very High Very High Very High
Schizophrenia 880 98.20 Very High Very High Very High
Congenital Anomalies 187 97.96 Very High Very High Very High
Death 24 95.24 Very High Very High Very High
Basal Cell Carcinoma 46 94.32 High High
Syndrome 56 93.04 High High
Drug Induced Neurotoxicity 4 90.76 High High
Toxicity 17 89.64 High High
Epidermal Cyst 1 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sexual differentiation of the brain, sexual dimorphism, and the vulnerability of schizophrenia have been linked in previous studies.4 One study described these so-called “gender effects in schizophrenia” as “the most robust phenomena of the disease, yet they have defied explanation ….”1 The effect of BPA and other endocrine disruptors on sexual development in animals has been reported by numerous investigators.
Regulation (effect) of BPA in brain associated with disease and schizophrenia
1) Confidence 0.11 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.52 Pain Relevance 0
BPA is a common ingredient of many plastic and resin products including food and drink containers, internal linings of food cans, and dental enamels.67 Also known as 2,2-bis(4-hydroxyphenyl) propane, BPA was invented in the 20th century68 and is manufactured by combining acetone and phenol.69 Emerging research indicates BPA is an estrogenic EDC that alters or interferes with normal endocrine development in various vertebrate and invertebrate species.70
Regulation (alters) of BPA in enamels
2) Confidence 0.11 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.44 Pain Relevance 0
Abnormalities of the cerebellum in several functional domains are reported in schizophrenia.86 The abnormalities include reduced cerebellar inhibition and reduced Purkinje cell size87,88 and alterations of factors controlling synaptogenesis.89 BPA, acting as an estrogen mimic, inhibits and disrupts estrogen-induced signaling in rats that regulates cell growth and death in the cerebellum.90 BPA also induces Purkinje dendritic growth in neonatal mice, the same effect that estrogen has on mouse Purkinje dendritic growth.91,92

Locus Coeruleus.

Regulation (controlling) of BPA in cerebellum associated with congenital anomalies, death and schizophrenia
3) Confidence 0.11 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.03 Pain Relevance 0.14
Galanin receptor 2 null mutant mice also exhibit an anxiogenic-like phenotype,222,223 which parallels the effects of BPA, DBP, DCHP, and DEHP injection in the midbrain of rats at 5 days of age that reduces gene expression of galanin receptor 2.172

[(35)S]GTP-gamma-S.

Regulation (effects) of BPA in midbrain associated with midbrain
4) Confidence 0.11 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.84 Pain Relevance 0.29
Recently, Wilson et al. reported the occurrence of hairy skin patches (discrete patches of unusually long pigmented hair) on the skin of three patients affected by Gorlin syndrome from two unrelated families with confirmed heterozygous mutations in the PTCH1 gene, suggesting that the patches may represent a sign associated with the syndrome [27].


Regulation (affected) of patches in hair associated with basal cell nevus syndrome and syndrome
5) Confidence 0.00 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 1.29 Pain Relevance 0

General Comments

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