INT256629

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.22
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1, Shh) extracellular region (Ptch1, Shh) plasma membrane (Ptch1, Shh)
anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
Anatomy Link Frequency
patterning 1
Ptch1 (Mus musculus)
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 76.16 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Neuronal excitability 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 58 99.44 Very High Very High Very High
Skin Cancer 10 98.76 Very High Very High Very High
Malignant Neoplastic Disease 15 97.60 Very High Very High Very High
Necrosis 5 84.92 Quite High
Basal Cell Nevus Syndrome 88 77.68 Quite High
Retinoblastoma 3 75.44 Quite High
Injury 36 72.24 Quite High
Syndrome 40 71.44 Quite High
Corneal Neovascularization 30 58.92 Quite High
Medulloblastoma 30 58.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTCH1 acts as a receptor for sonic hedgehog (SHH) [16] and seem to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis [17].
PTCH1 Binding (receptor) of SHH associated with cancer
1) Confidence 0.42 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0.18 Pain Relevance 0
PTCH1 acts as a receptor for sonic hedgehog (SHH) [16] and seem to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis [17].
PTCH1 Binding (receptor) of sonic hedgehog associated with cancer
2) Confidence 0.42 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0.18 Pain Relevance 0
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Ptc Binding (binding) of Shh
3) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Ptc Binding (binding) of Shh
4) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
patched 1 Binding (binding) of Shh
5) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Ptc Binding (binding) of Shh
6) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
patched 1 Binding (binding) of Shh
7) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04
PTCH1 in the absence of its ligand, SHH, acts a cell-cycle regulator, normally inhibiting expression of downstream genes that control cell fate, patterning, and growth [122].
PTCH1 Binding (ligand) of SHH in patterning
8) Confidence 0.14 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.61 Pain Relevance 0

General Comments

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