INT25663

Context Info Confidence 0.38 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.47 Pain Relevance 0.71

cytosol (PMAIP1) mitochondrion (PMAIP1) nucleus (PMAIP1)

Anatomy Link Frequency B-cell 1 PBMC 1 PMAIP1 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 1 100.00 Morphine 3 98.54 methadone 3 98.30 opiate 2 82.64 Inflammation 10 50.00 cytokine 9 41.36 narcan 1 25.00 imagery 5 5.00 anesthesia 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 1 100.00 Recurrence 21 98.56 Apoptosis 24 98.00 Rectal Cancer 22 96.86 Pressure Volume 2 Under Development 2 90.80 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 90.08 Disease 9 89.76 Sepsis 1 85.60 Death 12 84.76 Wound Healing 1 83.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27].

Localization (release) of Noxa in B-cell associated with lymphatic system cancer, antagonist and apoptosis

1) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.17 Pain Relevance 0.05

Also, culturing PBMC from healthy controls in the presence of methadone or morphine at concentrations as low as 10(-12) M caused significant suppression of PMA-stimulated O2- release.

Localization (release) of PMA-stimulated in PBMC associated with methadone and morphine

2) Confidence 0.15 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0.09 Pain Relevance 0.66

Our experience for these 180 patients with distal rectal cancer did demonstrate that there was a significantly reduced incidence of local recurrence when chemoradiation was given preoperatively, regardless of whether an APR or ULAR was performed.

Localization (performed) of APR associated with rectal cancer and recurrence

3) Confidence 0.05 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2859360 Disease Relevance 1.21 Pain Relevance 0

General Comments

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