INT25663

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.47
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PMAIP1) mitochondrion (PMAIP1) nucleus (PMAIP1)
Anatomy Link Frequency
B-cell 1
PBMC 1
PMAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 100.00 Very High Very High Very High
Morphine 3 98.54 Very High Very High Very High
methadone 3 98.30 Very High Very High Very High
opiate 2 82.64 Quite High
Inflammation 10 50.00 Quite Low
cytokine 9 41.36 Quite Low
narcan 1 25.00 Low Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 1 100.00 Very High Very High Very High
Recurrence 21 98.56 Very High Very High Very High
Apoptosis 24 98.00 Very High Very High Very High
Rectal Cancer 22 96.86 Very High Very High Very High
Pressure Volume 2 Under Development 2 90.80 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 90.08 High High
Disease 9 89.76 High High
Sepsis 1 85.60 High High
Death 12 84.76 Quite High
Wound Healing 1 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27].
Localization (release) of Noxa in B-cell associated with lymphatic system cancer, antagonist and apoptosis
1) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.17 Pain Relevance 0.05
Also, culturing PBMC from healthy controls in the presence of methadone or morphine at concentrations as low as 10(-12) M caused significant suppression of PMA-stimulated O2- release.
Localization (release) of PMA-stimulated in PBMC associated with methadone and morphine
2) Confidence 0.15 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0.09 Pain Relevance 0.66
Our experience for these 180 patients with distal rectal cancer did demonstrate that there was a significantly reduced incidence of local recurrence when chemoradiation was given preoperatively, regardless of whether an APR or ULAR was performed.
Localization (performed) of APR associated with rectal cancer and recurrence
3) Confidence 0.05 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2859360 Disease Relevance 1.21 Pain Relevance 0

General Comments

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