INT256646

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.83
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf, Nfkb1) mitochondrion (Nfkb1) intracellular (Tnf)
DNA binding (Nfkb1) extracellular matrix organization (Tnf) protein complex (Nfkb1)
Tnf (Rattus norvegicus)
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 8 99.96 Very High Very High Very High
Inflammation 24 97.96 Very High Very High Very High
Sciatic nerve 18 78.68 Quite High
Peripheral nerve injury 12 33.36 Quite Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 4 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
Nervous System Injury 18 98.76 Very High Very High Very High
INFLAMMATION 32 97.96 Very High Very High Very High
Neurological Disease 2 92.04 High High
Injury 16 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these cytokines, Tumor necrosis factor alpha (TNF-alpha), is known to induce nuclear factor kappab (NF-kappab) activation, a transcription factor that promotes further pro-inflammatory cytokine production in inflammatory cells [19].
TNF-alpha Positive_regulation (induce) of Positive_regulation (activation) of NF-kappab associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.22 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.91 Pain Relevance 0.45
One of these cytokines, Tumor necrosis factor alpha (TNF-alpha), is known to induce nuclear factor kappab (NF-kappab) activation, a transcription factor that promotes further pro-inflammatory cytokine production in inflammatory cells [19].
Tumor necrosis factor alpha Positive_regulation (induce) of Positive_regulation (activation) of NF-kappab associated with necrosis, inflammation, cancer and cytokine
2) Confidence 0.22 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.92 Pain Relevance 0.45

General Comments

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