INT256671

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Wfs1) neurological system process (Wfs1)
Anatomy Link Frequency
upper 2
Wfs1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 9 48.08 Quite Low
gABA 12 5.00 Very Low Very Low Very Low
Migraine 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 63 99.56 Very High Very High Very High
Manic Depressive Disorder 57 73.92 Quite High
Depression 9 48.08 Quite Low
Oxidative Phosphorylation Disease 9 41.92 Quite Low
Psychosis 3 38.92 Quite Low
Deafness 3 33.68 Quite Low
Optic Atrophy 3 33.16 Quite Low
Diabetes Mellitus 3 32.56 Quite Low
Diabetes Insipidus 3 31.80 Quite Low
Convulsion 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
phosphorylation levels (Figure 1A upper panel), raising the possibility that WFS1 upregulation by valproate is not regulated by the ER stress signaling network.
Neg (not) Regulation (regulated) of Positive_regulation (upregulation) of WFS1 in upper associated with stress
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.70 Pain Relevance 0
To determine whether PERK signaling is involved in WFS1 upregulation by valproate, we measured expression levels of phosphorylated eIF2?
Spec (whether) Regulation (involved) of Spec (whether) Positive_regulation (upregulation) of WFS1
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.72 Pain Relevance 0
The upregulation of WFS1 by valproate is probably regulated by the same element because the promoter lacking this sequence, pGL3-WFS1-short, did not respond to valproate (Figure 2).
Spec (probably) Regulation (regulated) of Positive_regulation (upregulation) of WFS1
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.35 Pain Relevance 0

General Comments

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