INT256673

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 8.49
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Anatomy Link Frequency
muscle 3
plasma 1
mesoderm 1
body 1
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 310 99.56 Very High Very High Very High
Inflammatory stimuli 24 97.52 Very High Very High Very High
cytokine 26 77.68 Quite High
Crohn's disease 51 69.16 Quite High
fibrosis 34 59.60 Quite High
addiction 2 50.00 Quite Low
anesthesia 17 5.00 Very Low Very Low Very Low
metalloproteinase 15 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 267 99.56 Very High Very High Very High
Myositis 336 99.34 Very High Very High Very High
Meningitis 3 98.16 Very High Very High Very High
Stress 312 97.88 Very High Very High Very High
Ureteral Obstruction 36 97.28 Very High Very High Very High
Injury 63 97.12 Very High Very High Very High
Infection 8 96.88 Very High Very High Very High
Manic Depressive Disorder 38 96.84 Very High Very High Very High
Muscle Disease 8 96.60 Very High Very High Very High
Death 24 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present article we showed that the Grp94 level increased in biopsies that displayed more than 3% of regenerating fibers, and this association was further experimentally validated in the laboratory mouse.
Positive_regulation (increased) of Grp94
1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.65 Pain Relevance 0.08
Except for sporadic inclusion-body myositis, where the ER chaperones calnexin, calreticulin, Grp78, Grp94 and ERp72 are upregulated and colocalize with intracellular aggregates [11,12], the present knowledge about changes in ER chaperone level and distribution among myofibers of myositis patients is far from complete.
Positive_regulation (upregulated) of Grp94 in body associated with myositis
2) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.67 Pain Relevance 0
Gp96 has already been reported to be a key mediator of the innate immune response due to its ability to bind pathogenic bacteria or their products.19–21 37 38 Indeed, Gp96 is a plasma membrane receptor for Vip, a Listeria monocytogenes virulence factor that is required for cell invasion and downstream signalling events.21 In addition, a Gp96 homologue, Ecgp96, the expression of which is increased during meningitis-associated E coli K1 infection of human BMECs, promotes invasion of these pathogenic bacteria.19 20 37
Positive_regulation (required) of gp96 in plasma associated with meningitis and infection
3) Confidence 0.49 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.68 Pain Relevance 0.06
Our data indicate that valproate enhances dissociation of WFS1 from GRP94.
Positive_regulation (enhances) of GRP94
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.35 Pain Relevance 0
Downregulation of GRP94 may increase the amount of GRP94-free WFS1, leading to the enhancement of WFS1 function.
Spec (may) Positive_regulation (increase) of GRP94
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.19 Pain Relevance 0
Grp94 is required for mesoderm induction and muscle cell differentiation [14], in so far as it redistributes after Fyn-mediated tyrosine phosphorylation in the secretory pathway [15], where it is probably involved in processing of insulin-like growth factor II [16], and, eventually, localizes at the cell surface, where it participates in myotube formation [13].
Positive_regulation (required) of Grp94 in mesoderm
6) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.47 Pain Relevance 0
Increased signals for Grp94 were observed in those patients of Group I who displayed the presence of regenerating myofibers (mean ± SEM Grp94/actin ratio, 3.23 ± 1.27; n = 5), compared with values observed in biopsies from Groups 0, I and II, in the absence of muscle regeneration (mean ± SEM Grp94/actin ratio, 0.43 ± 0.05; n = 6, P = 0.03).


Positive_regulation (Increased) of Grp94 in muscle
7) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.10 Pain Relevance 0
Our data show that the two types of ER stress-response detectable in the presence of autoimmune myositis reveal the presence and the degree of muscle regeneration, by means of increased Grp94 levels, and reveal the influence of systemic stressing stimuli, probably of inflammatory origin, which are responsible for the increased expression of Grp75.
Positive_regulation (increased) of Grp94 in muscle associated with stress, inflammation and myositis
8) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.95 Pain Relevance 0.12
The present study was undertaken to characterize in more detail the ER stress-response occurring in myofibers of patients with inflammatory myopathies, focusing on the expression and distribution of Grp94, calreticulin and Grp75, three ER chaperones involved in immunomodulation.


Positive_regulation (distribution) of Grp94 associated with stress and inflammation
9) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.83 Pain Relevance 0.16
Upregulation of Grp94 characterized regenerating myofibers of myositis patients (P = 0.03, compared with values detected in biopsies without signs of muscle regeneration) and developing and regenerating myofibers of mouse muscles.
Positive_regulation (Upregulation) of Grp94 in muscles associated with myositis
10) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.90 Pain Relevance 0.19
An earlier report showed that the Grp94 gene and protein were increased after exposure to WY or nafenopin [38].
Positive_regulation (increased) of Grp94 gene
11) Confidence 0.28 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.34 Pain Relevance 0
In line, we found a profound upregulation of tubulointerstitial Gp96, tubular biglycan and HMGB1 protein 14 days after the induction of UUO injury (Figure 3B).
Positive_regulation (upregulation) of Gp96 associated with ureteral obstruction and injury
12) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.58 Pain Relevance 0.03
At variance with Grp94, Grp75 protein levels increased significantly in myositis biopsies with negligible levels of regeneration, and especially in those displaying a restricted sarcolemmal MHC-I immunoreactivity to a few clusters of myofibers [40].
Positive_regulation (increased) of Grp94 associated with myositis
13) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.80 Pain Relevance 0.05

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