INT256680

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 34.56 Quite Low
gABA 12 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Migraine 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 57 98.20 Very High Very High Very High
Myositis 42 97.48 Very High Very High Very High
Stress 91 84.80 Quite High
Death 3 82.92 Quite High
Disease 6 55.52 Quite High
Targeted Disruption 1 38.92 Quite Low
INFLAMMATION 29 24.04 Low Low
Autoimmune Disease 1 22.12 Low Low
Oxidative Phosphorylation Disease 9 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downregulation of GRP94 may increase the amount of GRP94-free WFS1, leading to the enhancement of WFS1 function.
Negative_regulation (Downregulation) of GRP94
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.24 Pain Relevance 0
Thus, the downregulation of GRP94 may have the same effect as the upregulation of WFS1.
Negative_regulation (downregulation) of GRP94
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.18 Pain Relevance 0
Thus, inhibitors of GRP94 function could be a novel class of drug for bipolar disorder.
Negative_regulation (inhibitors) of GRP94 associated with manic depressive disorder
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.45 Pain Relevance 0
In particular, data concerning Grp94, calreticulin and Grp75 are presently lacking.
Negative_regulation (lacking) of Grp94
4) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.55 Pain Relevance 0

General Comments

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