INT256681

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.72
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Wfs1) neurological system process (Wfs1)
Anatomy Link Frequency
neurons 1
Neuro-2a 1
Wfs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 1 97.28 Very High Very High Very High
Dopamine 1 95.80 Very High Very High Very High
depression 22 93.20 High High
alcohol 1 57.12 Quite High
addiction 1 55.76 Quite High
Hippocampus 1 26.96 Quite Low
anticonvulsant 7 11.56 Low Low
gABA 28 9.04 Low Low
Migraine 7 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 147 99.74 Very High Very High Very High
Targeted Disruption 2 99.64 Very High Very High Very High
Anxiety Disorder 4 98.92 Very High Very High Very High
Manic Depressive Disorder 134 98.80 Very High Very High Very High
Depression 22 93.20 High High
Oxidative Phosphorylation Disease 21 87.04 High High
Psychosis 7 84.04 Quite High
Deafness 7 78.80 Quite High
Optic Atrophy 7 78.28 Quite High
Diabetes Mellitus 8 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3B shows that lithium treatment of Neuro-2a cells did not change the ratio between immunoprecipitated WFS1 and GRP94.
Neg (not) Regulation (change) of WFS1 in Neuro-2a
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
Eero Vasar and Sulev Kõks described the role of the Wfs1 gene in knockout mice for anxiety behavior, an altered response to morphine and the release of striatal dopamine (Koks et al. 2009; Luuk et al. 2009).
Regulation (role) of Wfs1 associated with targeted disruption, dopamine, anxiety disorder and morphine
2) Confidence 0.38 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2923724 Disease Relevance 0.62 Pain Relevance 0.20
Here we show that valproate modulates the ER stress response through the regulation of WFS1, an important component for mitigating ER stress.
Regulation (regulation) of WFS1 associated with stress
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2607540 Disease Relevance 0.63 Pain Relevance 0
Our data raise the possibility that the therapeutic effects of valproate in bipolar disorder may be mediated by the modulation of ER stress through the regulation of WFS1 and GRP94.


Regulation (regulation) of WFS1 associated with stress and manic depressive disorder
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.22 Pain Relevance 0.07
We propose that the therapeutic effect of valproate is partially mediated by modulation of ER stress through the regulation of WFS1 and GRP94.
Regulation (regulation) of WFS1 associated with stress
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.35 Pain Relevance 0
It would be possible that geldanamycin as well as its less toxic analogues, 17-AAG and GA, may synergize with valproate and increase its effect on WFS1 expression and modulation of the WFS1-GRP94 complex.
Regulation (modulation) of WFS1
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.44 Pain Relevance 0
Here we show that valproate regulates WFS1 and GRP94 in neurons.
Regulation (regulates) of WFS1 in neurons
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.45 Pain Relevance 0.09
Mood stabilizers modulate WFS1-GRP94 complex
Regulation (modulate) of WFS1
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0

General Comments

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