INT256682

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Context Info
Confidence 0.74
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 6.63
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Wfs1) neurological system process (Wfs1)
Anatomy Link Frequency
neuronal 1
SH-SY5Y 1
neurons 1
upper 1
Wfs1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 33 75.16 Quite High
gABA 44 5.00 Very Low Very Low Very Low
Migraine 11 5.00 Very Low Very Low Very Low
anticonvulsant 11 5.00 Very Low Very Low Very Low
Neurotransmitter 11 5.00 Very Low Very Low Very Low
GABAergic 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 209 99.60 Very High Very High Very High
Stress 231 98.92 Very High Very High Very High
Depression 33 75.16 Quite High
Oxidative Phosphorylation Disease 33 69.00 Quite High
Psychosis 11 66.00 Quite High
Deafness 11 60.76 Quite High
Optic Atrophy 11 60.24 Quite High
Diabetes Mellitus 11 59.64 Quite High
Diabetes Insipidus 11 58.88 Quite High
Convulsion 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WFS1 expression is regulated by the master regulators of ER stress signaling, PERK and IRE1?
Gene_expression (expression) of WFS1 associated with stress
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.72 Pain Relevance 0.03
Another mood stabilizer, lithium, did not increase WFS1 expression levels significantly in these cells (Figure 1A, lower panel).
Gene_expression (expression) of WFS1
2) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.71 Pain Relevance 0.03
Valproate increased WFS1 expression levels in a dose-dependent manner (Figure 3A, lanes 5 and 6, lower panels, input).
Gene_expression (expression) of WFS1
3) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.06 Pain Relevance 0
To test this idea, we co-transfected SH-SY5Y cells with XBP-1 expression plasmid along with the WFS1 reporter plasmid or the control plasmid with or without valproate treatment.
Gene_expression (expression) of WFS1 in SH-SY5Y
4) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.11 Pain Relevance 0
Valproate increased WFS1 protein expression levels in Neuro-2a cells with a peak at 24 hr (Figure 1A, upper panel).
Gene_expression (expression) of WFS1 in upper
5) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.83 Pain Relevance 0.06
To investigate the possible involvement of valproate in WFS1 function in neurons, we first determined expression levels of WFS1 in neuronal cell lines treated with a therapeutic concentration of valproate.
Spec (determined) Gene_expression (expression) of WFS1 in neuronal
6) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.08 Pain Relevance 0.06
Valproate increases the expression of WFS1 without inducing other ER stress markers
Gene_expression (expression) of WFS1 associated with stress
7) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.25 Pain Relevance 0.07
Our results demonstrate that valproate induces expression of WFS1 and enhances its dissociation from GRP94 in neurons.
Gene_expression (expression) of WFS1 in neurons
8) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.32 Pain Relevance 0
In this study, we focused on the function of valproate in WFS1 expression and its interaction with GRP94.
Gene_expression (expression) of WFS1
9) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.48 Pain Relevance 0
It would be possible that geldanamycin as well as its less toxic analogues, 17-AAG and GA, may synergize with valproate and increase its effect on WFS1 expression and modulation of the WFS1-GRP94 complex.
Gene_expression (expression) of WFS1
10) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.44 Pain Relevance 0
These results suggest that the therapeutic effects of valproate in bipolar disorder may be mediated by WFS1 expression and its dissociation from GRP94.



Gene_expression (expression) of WFS1 associated with manic depressive disorder
11) Confidence 0.57 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2607540 Disease Relevance 0.65 Pain Relevance 0

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