INT256684

Context Info Confidence 0.66 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 3.62 Pain Relevance 0.16

endoplasmic reticulum (Wfs1) neurological system process (Wfs1)

Anatomy Link Frequency neurons 2 upper 2 Wfs1 (Mus musculus)

Pain Link Frequency Relevance Heat depression 18 75.72 gABA 24 5.00 Migraine 6 5.00 anticonvulsant 6 5.00 Neurotransmitter 6 5.00 GABAergic 6 5.00

Disease Link Frequency Relevance Heat Stress 126 98.92 Manic Depressive Disorder 114 95.64 Depression 18 75.72 Oxidative Phosphorylation Disease 18 69.56 Psychosis 6 66.56 Deafness 6 61.32 Optic Atrophy 6 60.80 Diabetes Mellitus 6 60.20 Diabetes Insipidus 6 59.44 Convulsion 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another mood stabilizer, lithium, did not increase WFS1 expression levels significantly in these cells (Figure 1A, lower panel).

Neg (not) Positive_regulation (increase) of Gene_expression (expression) of WFS1

1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.71 Pain Relevance 0.03

Valproate increased WFS1 expression levels in a dose-dependent manner (Figure 3A, lanes 5 and 6, lower panels, input).

Positive_regulation (increased) of Gene_expression (expression) of WFS1

2) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.06 Pain Relevance 0

Valproate increased WFS1 protein expression levels in Neuro-2a cells with a peak at 24 hr (Figure 1A, upper panel).

Positive_regulation (increased) of Gene_expression (expression) of WFS1 in upper

3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.84 Pain Relevance 0.06

Our results demonstrate that valproate induces expression of WFS1 and enhances its dissociation from GRP94 in neurons.

Positive_regulation (induces) of Gene_expression (expression) of WFS1 in neurons

4) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.32 Pain Relevance 0

Valproate increases the expression of WFS1 without inducing other ER stress markers

Positive_regulation (increases) of Gene_expression (expression) of WFS1 associated with stress

5) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.25 Pain Relevance 0.07

It would be possible that geldanamycin as well as its less toxic analogues, 17-AAG and GA, may synergize with valproate and increase its effect on WFS1 expression and modulation of the WFS1-GRP94 complex.

Positive_regulation (increase) of Gene_expression (expression) of WFS1

6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.44 Pain Relevance 0

General Comments

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