INT256684

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.62
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Wfs1) neurological system process (Wfs1)
Anatomy Link Frequency
neurons 2
upper 2
Wfs1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 18 75.72 Quite High
gABA 24 5.00 Very Low Very Low Very Low
Migraine 6 5.00 Very Low Very Low Very Low
anticonvulsant 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
GABAergic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 126 98.92 Very High Very High Very High
Manic Depressive Disorder 114 95.64 Very High Very High Very High
Depression 18 75.72 Quite High
Oxidative Phosphorylation Disease 18 69.56 Quite High
Psychosis 6 66.56 Quite High
Deafness 6 61.32 Quite High
Optic Atrophy 6 60.80 Quite High
Diabetes Mellitus 6 60.20 Quite High
Diabetes Insipidus 6 59.44 Quite High
Convulsion 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another mood stabilizer, lithium, did not increase WFS1 expression levels significantly in these cells (Figure 1A, lower panel).
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of WFS1
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.71 Pain Relevance 0.03
Valproate increased WFS1 expression levels in a dose-dependent manner (Figure 3A, lanes 5 and 6, lower panels, input).
Positive_regulation (increased) of Gene_expression (expression) of WFS1
2) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.06 Pain Relevance 0
Valproate increased WFS1 protein expression levels in Neuro-2a cells with a peak at 24 hr (Figure 1A, upper panel).
Positive_regulation (increased) of Gene_expression (expression) of WFS1 in upper
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.84 Pain Relevance 0.06
Our results demonstrate that valproate induces expression of WFS1 and enhances its dissociation from GRP94 in neurons.
Positive_regulation (induces) of Gene_expression (expression) of WFS1 in neurons
4) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.32 Pain Relevance 0
Valproate increases the expression of WFS1 without inducing other ER stress markers
Positive_regulation (increases) of Gene_expression (expression) of WFS1 associated with stress
5) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.25 Pain Relevance 0.07
It would be possible that geldanamycin as well as its less toxic analogues, 17-AAG and GA, may synergize with valproate and increase its effect on WFS1 expression and modulation of the WFS1-GRP94 complex.
Positive_regulation (increase) of Gene_expression (expression) of WFS1
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.44 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox