INT256693

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Wfs1) neurological system process (Wfs1)
Anatomy Link Frequency
neuronal 1
Wfs1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 9 89.72 High High
anticonvulsant 3 8.08 Low Low
gABA 12 5.56 Low Low
Migraine 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 63 98.48 Very High Very High Very High
Manic Depressive Disorder 57 95.32 Very High Very High Very High
Depression 9 89.72 High High
Oxidative Phosphorylation Disease 9 83.56 Quite High
Psychosis 3 80.56 Quite High
Deafness 3 75.32 Quite High
Optic Atrophy 3 74.80 Quite High
Diabetes Mellitus 3 74.20 Quite High
Diabetes Insipidus 3 73.44 Quite High
Convulsion 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been proposed that WFS1 mRNA expression is regulated by a 500-base-pair promoter region located upstream of its transcriptional start site [22].
Transcription (expression) of WFS1
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.50 Pain Relevance 0
Valproate activates the WFS1 promoter and induces WFS1 mRNA expression in neuronal cells.
Transcription (expression) of WFS1 in neuronal
2) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.33 Pain Relevance 0.08
Therapeutic concentrations of valproate induce expression of WFS1 mRNA and activate the WFS1 promoter.
Transcription (expression) of WFS1
3) Confidence 0.51 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2607540 Disease Relevance 0.62 Pain Relevance 0

General Comments

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