INT256706

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 5.02
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hsp90b1, Wfs1) unfolded protein binding (Hsp90b1) protein folding (Hsp90b1)
cytosol (Hsp90b1) RNA binding (Hsp90b1) neurological system process (Wfs1)
Anatomy Link Frequency
upper 2
Neuro-2a 2
Hsp90b1 (Mus musculus)
Wfs1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 33 87.12 High High
anticonvulsant 11 46.56 Quite Low
gABA 44 44.04 Quite Low
GABAergic 11 39.28 Quite Low
Neurotransmitter 11 33.40 Quite Low
Migraine 11 30.20 Quite Low
Disease Link Frequency Relevance Heat
Stress 231 99.68 Very High Very High Very High
Manic Depressive Disorder 209 96.64 Very High Very High Very High
Depression 33 87.12 High High
Oxidative Phosphorylation Disease 33 85.28 High High
Diabetes Insipidus 11 79.60 Quite High
Diabetes Mellitus 11 78.00 Quite High
Psychosis 11 77.96 Quite High
Optic Atrophy 11 76.48 Quite High
Deafness 11 75.04 Quite High
Convulsion 22 42.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm this, we examined the association of WFS1 with GRP94 in Neuro-2a cells by immunoprecipitation.
GRP94 Spec (examined) Binding (association) of WFS1 in Neuro-2a
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
The amount of GRP94 co-immunoprecipitated with WFS1 was decreased with lithium (Figure 3A, lanes 3 and 4, upper panels).
GRP94 Binding (immunoprecipitated) of WFS1 in upper
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
As we predicted, WFS1 associated with GRP94 under normal conditions (Figure 3A, lane 2, upper panels, IP).
GRP94 Binding (associated) of WFS1 in upper
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
High throughput proteomics analysis revealed that GRP94 interacts with WFS1 protein (Fonseca and Urano, unpublished data).
GRP94 Binding (interacts) of WFS1
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.15 Pain Relevance 0.03
High-throughput proteomics analysis has shown that WFS1 interacts with GRP94 (Fonseca and Urano, manuscript in preparation).
GRP94 Binding (interacts) of WFS1
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
High-throughput proteomics analysis revealed that GRP94 was one of the proteins that could interact with WFS1 in 293T cells (Fonseca and Urano, manuscript in preparation).
GRP94 Binding (interact) of WFS1
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.34 Pain Relevance 0
Under normal conditions, WFS1 forms a complex with GRP94 and valproate enhances its dissociation from GRP94.
GRP94 Binding (complex) of WFS1
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.31 Pain Relevance 0.08
To test this possibility, we treated Neuro-2a cells with therapeutic concentrations of lithium or valproate for 48 hr, then examined the interaction between WFS1 and GRP94 by immunoprecipitation.
GRP94 Spec (examined) Binding (interaction) of WFS1 in Neuro-2a
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
Considered collectively, valproate may regulate the UPR by modulating the interaction between GRP94 and WFS1.
GRP94 Binding (interaction) of WFS1
9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.30 Pain Relevance 0
In addition, WFS1 forms a complex with GRP94, an ER stress-response protein, in which valproate dose-dependently enhances its dissociation from GRP94.


GRP94 Binding (complex) of WFS1 associated with stress
10) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2607540 Disease Relevance 0.61 Pain Relevance 0
Under normal conditions, WFS1 forms a complex with GRP94 and valproate enhances its dissociation from GRP94.
GRP94 Binding (forms) of WFS1
11) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.31 Pain Relevance 0.08

General Comments

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