INT25674

Context Info Confidence 0.60 First Reported 1987 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 16 Total Number 17 Disease Relevance 7.46 Pain Relevance 3.12

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)

Anatomy Link Frequency neutrophil 12 chondrocytes 2 blood 2 macrophages 2 RKO 2 ELANE (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 9 100.00 Dopamine 94 99.80 rheumatoid arthritis 54 98.86 Inflammation 98 98.08 diclofenac 12 96.64 Spinal cord 2 96.56 qutenza 4 95.44 chemokine 42 91.20 Neuropathic pain 5 90.00 Sciatic nerve 1 87.84

Disease Link Frequency Relevance Heat Cv General 3 Under Development 8 100.00 Myocardial Infarction 5 100.00 Disease 52 99.72 Hemarthrosis 4 99.62 Rheumatoid Arthritis 54 98.86 INFLAMMATION 110 98.08 Apoptosis 78 97.84 Marinesco Sjogren Syndrome 2 97.72 Neutrophil Disorders 67 96.08 Agranulocytosis 51 96.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

No causative ELA2 mutations were found, and therapeutic concentrations of sulphasalazine did not increase the expression of human neutrophil elastase.

Neg (not) Positive_regulation (increase) of Gene_expression (expression) of elastase in neutrophil

1) Confidence 0.60 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.58 Pain Relevance 0

causes accumulation of canine neutrophil elastase in the cytosolic compartments [12], and mutations in ELA2 may disrupt the AP3?

Positive_regulation (accumulation) of Gene_expression (mutations) of ELA2 in neutrophil

2) Confidence 0.50 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.62 Pain Relevance 0

causes accumulation of canine neutrophil elastase in the cytosolic compartments [12], and mutations in ELA2 may disrupt the AP3?

Positive_regulation (accumulation) of Gene_expression (mutations) of elastase in neutrophil

3) Confidence 0.43 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.62 Pain Relevance 0

Plasma levels of peptide B beta, a product of fibrin degradation by human neutrophil elastase, were approximately 15-fold higher (p less than 0.001) in patients with unstable angina or AMI (588 +/- 171 pmol/l, mean +/- SEM) compared with those in patients with stable angina (37 +/- 25 pmol/l) or control subjects (40 +/- 22 pmol/l), confirming intense in vivo neutrophil activation.

Positive_regulation (confirming) of Gene_expression (product) of elastase in neutrophil associated with angina and myocardial infarction

4) Confidence 0.43 Published 1989 Journal Circulation Section Abstract Doc Link 2537159 Disease Relevance 1.60 Pain Relevance 0.80

To examine whether this reduction is attributed to HNE depletion, cells were stimulated with either single or repeated 10 ?

Spec (whether) Positive_regulation (attributed) of Gene_expression (depletion) of HNE

5) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0

1 production could be involved in HNE-induced 5-LOX and FLAP expression, chondrocytes were treated or not with a single addition of 10 ?

Positive_regulation (involved) of Gene_expression (expression) of HNE-induced in chondrocytes

6) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03

The PMN production of superoxide anion induced by various FMLP concentrations (10(-7), 10(-6) and 10(-5) M) was also decreased by diclofenac.

Positive_regulation (induced) of Gene_expression (production) of PMN in PMN associated with diclofenac

7) Confidence 0.18 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3300657 Disease Relevance 0.08 Pain Relevance 0.41

To prioritize our studies of the relation between protein modification and cellular responses, we constructed expression vectors containing individual response elements upstream of the luciferase gene, which we transfected into RKO cells prior to treatment with HNE.

Positive_regulation (transfected) of Gene_expression (transfected) of HNE in RKO

8) Confidence 0.16 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.36 Pain Relevance 0

Another effect of HNE, also important for cell

Positive_regulation (effect) of Gene_expression (effect) of HNE

9) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.07 Pain Relevance 0

Another effect of HNE, also important for cell

Positive_regulation (important) of Gene_expression (effect) of HNE

10) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.07 Pain Relevance 0

This raises the question of the pharmacological actions of atomoxetine, which also increases extrasynaptic levels of NE and DA in the PFC.

Positive_regulation (increases) of Gene_expression (levels) of NE associated with dopamine

11) Confidence 0.04 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0 Pain Relevance 0.25

Pretreatment with beraprost attenuated AGML and downregulated the expression of HNE and HO-1, while sensory denervation aggravated AGML and upregulated the expression of HNE and HO-1.

Positive_regulation (upregulated) of Gene_expression (expression) of HNE

12) Confidence 0.03 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.18 Pain Relevance 0.08

Increased HNE levels have also been found in the cerebellum of patients with spinocerebellar degeneration [235].

Positive_regulation (Increased) of Gene_expression (levels) of HNE in cerebellum associated with marinesco sjogren syndrome

13) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.64 Pain Relevance 0.07

After AGML, increased generation of HNE was observed in the injured mucosa and the surrounding submucosa, followed by nuclear translocation of Nrf2 and upregulation of HO-1 in the macrophages located in the margin of the injured mucosa and in the submucosa.

Positive_regulation (increased) of Gene_expression (generation) of HNE in macrophages

14) Confidence 0.03 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.21 Pain Relevance 0.10

Neutrophils in acute hemarthrosis are activated and produce increased levels of reactive oxygen species, elastase and other lysosomal enzymes [18].

Positive_regulation (increased) of Gene_expression (produce) of elastase in Neutrophils associated with hemarthrosis

15) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 1.06 Pain Relevance 0.14

Notably, no significant levels of CCL18 mRNA were detectable in blood PMN form RA patients (n = 9; Figure 2b), suggesting that CCL18 gene expression in SF PMN occurs as a result of the recruitment of PMN into the inflammatory milieu of the joint.

Positive_regulation (occurs) of Gene_expression (expression) of PMN in blood associated with inflammation and rheumatoid arthritis

16) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.54 Pain Relevance 0.47

The main findings were found seven days after SNT, when there was an increase in HNE-Michael adducts formation, total and p-Akt expression, and H(2)O(2) concentration.

Positive_regulation (increase) of Gene_expression (expression) of HNE

17) Confidence 0.01 Published 2008 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 18379870 Disease Relevance 0.78 Pain Relevance 0.78

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