INT256742

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 2.89
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
anterior 1
Cdr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 69 84.16 Quite High
Sciatica 35 83.12 Quite High
Facet joint 5 42.80 Quite Low
imagery 5 36.40 Quite Low
Spinal cord 5 24.56 Low Low
Disease Link Frequency Relevance Heat
Disease 106 99.90 Very High Very High Very High
Sprains And Strains 504 98.76 Very High Very High Very High
Parkinson's Disease 27 87.44 High High
Pain 69 84.16 Quite High
Nerve Root Compression 35 83.12 Quite High
Spinal Cord Diseases 30 81.60 Quite High
Hoarseness 5 80.88 Quite High
Voice Disorders 5 80.24 Quite High
Aphasia 5 79.80 Quite High
Attention Deficit Hyperactivity Disorder 36 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was performed on 23 patients with degenerative cervical disc disease who underwent CDR using the Mobi-C disc prosthesis between March and June 2006.
Positive_regulation (underwent) of CDR associated with disease
1) Confidence 0.27 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628079 Disease Relevance 0.10 Pain Relevance 0
One patient underwent CDR with Mobi-C disc prostheses in two levels.
Positive_regulation (underwent) of CDR
2) Confidence 0.18 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628079 Disease Relevance 0.50 Pain Relevance 0.42
Both Odom's criteria and Prolo economic and function rating scale were good In 1 patient who underwent CDR with Mobi-C disc prostheses in two levels and in the 2 patients who previously underwent anterior cervical fusion.


Positive_regulation (underwent) of CDR in anterior
3) Confidence 0.18 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628079 Disease Relevance 0.67 Pain Relevance 0.24
We evaluated the clinical results and dynamics of 23 patients who underwent CDR using the Mobi-C disc prosthesis (LDR medical, Troyes, France).


Positive_regulation (underwent) of CDR
4) Confidence 0.18 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628079 Disease Relevance 0.06 Pain Relevance 0
This study was performed on 23 patients with degenerative cervical disc disease who underwent CDR with Mobi-C disc prosthesis from March 2006 to June 2006.


Positive_regulation (underwent) of CDR associated with disease
5) Confidence 0.18 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628079 Disease Relevance 0.26 Pain Relevance 0.16
In some cases, significant upregulation (from 13- to 170-fold) of only CgCDR1 was measured (DSY2268, DSY2273, DSY754, DSY2315, DSY565 and DSY2746).
Positive_regulation (upregulation) of CgCDR1
6) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.23 Pain Relevance 0
For example, the presence of the Y584C substitution (from CgPDR1 of DSY754) led to CgCDR1 upregulation only (17- and 12-fold expression increase, Figure 1 and Figure 6B), whereas the presence of the T588A substitution (from CgPDR1 of DSY2234) resulted in high mRNA levels of both CgCDR genes (4- and 8-fold expression increase for CgCDR1, 23- and 30-fold increase for CgCDR2, Figure 1 and Figure 6B).
Positive_regulation (upregulation) of CgCDR1
7) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.18 Pain Relevance 0
For example, two distinct mutations in the KIX domain, E1083Q (in DSY530) and D1082G (in DSY2254), gave selective upregulation of CgCDR1 alone or both CgCDR1 and CgCDR2, respectively.
Positive_regulation (upregulation) of CgCDR1
8) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.08 Pain Relevance 0
In this collection, azole-resistant isolates upregulated at least one of the ABC-transporter genes including CgCDR1, CgCDR2 or CgSNQ2 (see Figure 1 for ABC-transporter genes expression levels measured by real-time RT-PCR in groups of isolates and Figure S1 for CgCdr1p and CgCdr2p levels determined by western blot).
Positive_regulation (upregulated) of CgCDR1
9) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0 Pain Relevance 0
Upregulation of CgCDR1 and CgCDR2 in azole-resistant isolates followed similar patterns but without reaching statistical significance (data not shown).
Positive_regulation (Upregulation) of CgCDR1
10) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.13 Pain Relevance 0
Consistent with this observation, upregulation of CgCDR1 and CgCDR2 in azole-resistant strains is correlated with an increase of CgPDR1 expression [14],[15].
Positive_regulation (upregulation) of CgCDR1 associated with sprains and strains
11) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.26 Pain Relevance 0
Although CgCDR1 was upregulated in the remaining isolate DSY717, no CgPDR1 mutation could be detected.
Positive_regulation (upregulated) of CgCDR1
12) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.16 Pain Relevance 0
To evaluate whether the expression level of CgPDR1 is important for the upregulation of CgCDR genes in our isolates, the CgPDR1 mRNA levels of 21 matched pairs of azole-susceptible and azole-resistant isolates (listed in Table 1) were quantified by slot blot analysis and real-time RT-PCR (Figure 3).
Positive_regulation (upregulation) of CgCDR
13) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.12 Pain Relevance 0
For example, the presence of the Y584C substitution (from CgPDR1 of DSY754) led to CgCDR1 upregulation only (17- and 12-fold expression increase, Figure 1 and Figure 6B), whereas the presence of the T588A substitution (from CgPDR1 of DSY2234) resulted in high mRNA levels of both CgCDR genes (4- and 8-fold expression increase for CgCDR1, 23- and 30-fold increase for CgCDR2, Figure 1 and Figure 6B).
Positive_regulation (increase) of CgCDR1
14) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.16 Pain Relevance 0

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