INT256851

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.71
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa8) protein folding (Hspa8) cytosol (Hspa8)
intracellular (Hspa8) protein complex (Hspa8) response to stress (Hspa8)
Anatomy Link Frequency
lungs 2
ovaries 1
Hspa8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 68.24 Quite High
cytokine 8 12.40 Low Low
Action potential 15 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Peripheral nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 50 100.00 Very High Very High Very High
Death 13 99.68 Very High Very High Very High
Stress 72 99.56 Very High Very High Very High
Infection 87 98.88 Very High Very High Very High
Viral Infection 18 95.76 Very High Very High Very High
Hepatitis C Virus Infection 3 94.96 High High
Hepatitis 3 94.44 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 91.08 High High
Drug Induced Neurotoxicity 4 74.60 Quite High
Apoptosis 88 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amongst the common down-regulated genes, there was a general predominance of genes normally involved in cell stress/death (Cybb, Mapk13, Hspa8) or transcriptional regulation (E2f8, Snrpe).


Regulation (regulation) of Hspa8 associated with stress and death
1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.29 Pain Relevance 0
Hspa8 (heat shock protein 70 kDa) was down- regulated in the 40% CR and IF ovaries.
Regulation (regulated) of Hspa8 in ovaries associated with shock
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.10 Pain Relevance 0.03
In the present study, HSPA8 was up-regulated continuously after H-PRRSV infection.
Regulation (regulated) of HSPA8 associated with infection
3) Confidence 0.10 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 1.48 Pain Relevance 0
Hsc70 is targeted to a particular substrate through binding to the “J domain” of its partner and regulates the conformation and activity of the target protein via mechanisms that appear to involve cycles of substrate binding and release, which are governed by ATP binding and hydrolysis.
Regulation (regulates) of Hsc70
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883571 Disease Relevance 0 Pain Relevance 0
The quantities of three proteins related to stress response were found to have been modified in either H-PRRSV-infected lungs or N-PRRSV-infected lungs, including heat shock 70 kDa protein 8 (HSPA8, Hsp70), heat shock 27 kDa protein 1 (HSPB1), and stress-induced-phosphoprotein 1.
Regulation (modified) of HSPA8 in lungs associated with stress and shock
5) Confidence 0.06 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.93 Pain Relevance 0
The quantities of three proteins related to stress response were found to have been modified in either H-PRRSV-infected lungs or N-PRRSV-infected lungs, including heat shock 70 kDa protein 8 (HSPA8, Hsp70), heat shock 27 kDa protein 1 (HSPB1), and stress-induced-phosphoprotein 1.
Regulation (modified) of heat shock 70 kDa protein 8 in lungs associated with stress and shock
6) Confidence 0.06 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.92 Pain Relevance 0

General Comments

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