INT256860

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
monocyte 2
female reproductive tract 2
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 46 88.92 High High
Analgesic 12 74.60 Quite High
palliative 1 64.24 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain management 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 12 100.00 Very High Very High Very High
Osteoporosis 1 99.72 Very High Very High Very High
Osteolysis 2 98.88 Very High Very High Very High
Hypercalcemia 4 90.36 High High
Pain 50 88.92 High High
Metastasis 31 87.72 High High
Adhesions 2 67.72 Quite High
Stress 9 60.16 Quite High
Prostate Cancer 22 54.64 Quite High
Paraplegia 1 50.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteoclastic expansion is reduced (inhibitor of tumor growth factor) and differentiation of macrophage – monocyte precursors is impeded (Coleman 1991; Warrel 1992; Rogers et al 1997; Major et al 2000).
Negative_regulation (reduced) of Negative_regulation (inhibitor) of tumor growth factor in monocyte associated with cancer and osteoporosis
1) Confidence 0.16 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770417 Disease Relevance 1.18 Pain Relevance 0.50
The 40% CR females also showed a down-regulation in the vascular endothelial growth factor (VEGF) signaling pathway, which plays an essential role in angiogenesis and follicle development within the female reproductive tract [37]–[39].
Negative_regulation (down) of Negative_regulation (regulation) of growth factor in female reproductive tract
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.13 Pain Relevance 0

General Comments

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