INT256864

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tp63) nucleoplasm (Tp63) anatomical structure formation involved in morphogenesis (Tp63)
Golgi apparatus (Tp63) nucleolus (Tp63) nucleus (Tp63)
Anatomy Link Frequency
notch 1
Tp63 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 98.74 Very High Very High Very High
cytokine 8 98.24 Very High Very High Very High
Bile 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 98.74 Very High Very High Very High
Adhesions 4 64.32 Quite High
Death 2 56.56 Quite High
Stress 18 56.32 Quite High
Shock 14 45.44 Quite Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Male Breast Neoplasms 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the up-regulated pathways unique to the 40% CR males, certain functional activities were heavily represented, i.e. immune/inflammatory function (CD44_UP, cd40, inflam, nthi), energy regulation (FA biosynth, GLUCO, GLUT_DOWN, GLYCOGEN, KET, electrontransport, ets) and cell development (PROLIF_GENE, cell_prolif, cellcyclearrest, eif2).
Gene_expression (biosynth) of KET associated with inflammation
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.30 Pain Relevance 0.09
Among the up-regulated pathways unique to the 20% CR, there was a dominance of signaling routes involved in energy metabolism (Butanoate, FA biosynthesis, KET, malate, malatex, ketone), immune function/cytokine activity (ANTI_CD44, nfkb, ctl, notch, lair) and development/differentiation (ST_Diff, cd40, notch, pkc, shh_lisa).
Gene_expression (biosynthesis) of KET in notch associated with cytokine
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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