INT256897

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.77
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (BAG3) cytosol (BAG3) plasma membrane (BAG3)
cytoplasm (BAG3)
IGKV1D-39 (Homo sapiens)
BAG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 15 100.00 Very High Very High Very High
epidural 3 100.00 Very High Very High Very High
isoflurane 3 98.96 Very High Very High Very High
Versed 9 67.32 Quite High
analgesia 9 53.92 Quite High
Regional anesthesia 3 26.60 Quite Low
lidocaine 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 147 100.00 Very High Very High Very High
Unconsciousness 3 88.08 High High
Vomiting 6 37.08 Quite Low
Anxiety Disorder 6 21.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Park et al10 reported that N2O when used for sedation during epidural anesthesia does not have the expected effect on BIS signals.
N2O Regulation (effect) of BIS associated with anesthesia, epidural and sleep disorders
1) Confidence 0.04 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.66 Pain Relevance 0.38
The authors emphasized the stimulatory changes at lower and higher frequency ranges of EEG, which decreased at low N2O concentration.15 Ramesh at al28 suggested that N2O affects BIS values in patients under isoflurane anesthesia.
N2O Regulation (affects) of BIS associated with anesthesia and isoflurane
2) Confidence 0.04 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.60 Pain Relevance 0.37
It is currently used most commonly intraoperatively to monitor the effects of anesthetic and sedative agents as a means of judging the depth of sedation or anesthesia.12,13 Bispectral index monitoring is suggested to non anesthesiologist in order to avoid too deep sedation.14 Some studies have shown a significant correlation between BIS and OAA/S scores by using different sedative drugs with N2O/O2, but others have shown that N2O has no effect on BIS in human volunteers when used solely.10,13,15,16 The other researchers showed that paradoxical changes might occur at BIS values during induction of anesthesia.13,17–19 Although N2O has been widely used as an anesthetic adjuvant, its effect on EEG activity is poorly understood because it is usually studied in the presence of additional anesthetics, including inhaled anesthetics.
N2O Neg (no) Regulation (effect) of BIS associated with anesthesia and sleep disorders
3) Confidence 0.04 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.51 Pain Relevance 0.19

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