INT2569

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 120
Total Number 121
Disease Relevance 26.29
Pain Relevance 26.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
brain 10
neurons 5
hippocampus 3
cortex 3
neuronal 3
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 110 100.00 Very High Very High Very High
depression 22 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
antidepressant 1 100.00 Very High Very High Very High
Enkephalin 74 99.96 Very High Very High Very High
substance P 19 99.96 Very High Very High Very High
antinociception 3 99.96 Very High Very High Very High
agonist 30 99.92 Very High Very High Very High
Neuropeptide 16 99.80 Very High Very High Very High
qutenza 8 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 24 100.00 Very High Very High Very High
Targeted Disruption 21 99.98 Very High Very High Very High
Cognitive Disorder 424 99.80 Very High Very High Very High
Neurodegenerative Disease 31 99.78 Very High Very High Very High
Poisoning 94 99.76 Very High Very High Very High
Pain 12 99.56 Very High Very High Very High
Hyperammonemia 76 99.40 Very High Very High Very High
Cirrhosis 364 99.32 Very High Very High Very High
Diabetes Mellitus 168 99.28 Very High Very High Very High
Liver Failure 192 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetylcholinesterase expressed in terms of wet weight was found to increase in the cerebellum, medulla, and to decrease in the medial cortex, hippocampus, thalamus and caudate nucleus.
Gene_expression (expressed) of Acetylcholinesterase in cerebellum associated with medulla, thalamus and hippocampus
1) Confidence 0.78 Published 1979 Journal Zh. Evol. Biokhim. Fiziol. Section Abstract Doc Link 473984 Disease Relevance 0.21 Pain Relevance 0.28
Factors regulating the expression of acetylcholinesterase-containing neurons in striatal cultures: effects of chemical depolarization.
Gene_expression (expression) of acetylcholinesterase in neurons
2) Confidence 0.78 Published 1990 Journal Brain Res. Section Title Doc Link 2178031 Disease Relevance 0 Pain Relevance 0.06
Fast and slow skeletal muscles express a common basic profile of acetylcholinesterase molecular forms.
Gene_expression (express) of acetylcholinesterase in skeletal muscles
3) Confidence 0.78 Published 1997 Journal Am. J. Physiol. Section Title Doc Link 9038812 Disease Relevance 0.12 Pain Relevance 0.20
Intraocular injections of tetrodotoxin reduce transiently expressed acetylcholinesterase activity in developing rat visual cortex.
Gene_expression (expressed) of acetylcholinesterase in cortex associated with tetrodotoxin
4) Confidence 0.78 Published 1989 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 2706772 Disease Relevance 0 Pain Relevance 0.37
These data demonstrate that normal innervation and afferent activity are necessary for the transient expression of AChE activity by geniculocortical neurons.
Gene_expression (expression) of AChE in neurons
5) Confidence 0.78 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0.09 Pain Relevance 0.54
Our results show that globular and asymmetric forms of AChE are both synthesized more rapidly in fibrillating than in nonfibrillating myotubes.
Gene_expression (synthesized) of AChE in myotubes
6) Confidence 0.78 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6693937 Disease Relevance 0.12 Pain Relevance 0.11
One hour after righting reflex recovery, the escape latencies of all the rats were recorded again, and the level of AChE expression in the forebrain cortex was measured quantitatively.
Gene_expression (expression) of AChE in cortex
7) Confidence 0.78 Published 2008 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 18250048 Disease Relevance 0.06 Pain Relevance 0
The effect of prenatal exposure to methadone via maternal osmotic minipumps on the expression of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) has been studied by light microscopy in the striatum of male and female rats.
Gene_expression (expression) of acetylcholinesterase in striatum associated with methadone
8) Confidence 0.77 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149590 Disease Relevance 0 Pain Relevance 0.31
[Acetylcholinesterase expression and changes in the electrical excitability of neuroblastoma cells during their morphological differentiation induced by an increase in the pH of the medium].
Gene_expression (expression) of Acetylcholinesterase associated with neuroblastoma
9) Confidence 0.76 Published 1988 Journal Tsitologiia Section Title Doc Link 2453961 Disease Relevance 0.19 Pain Relevance 0.10
As AChE is present as both active and inactive subunits (Rotundo, 1988; Chatel et al., 1993; García-Ayllón et al., 2006, 2007), we performed immunoblotting to assess whether altered activity levels correlated with increases in the total pool of AChE protein.
Neg (inactive) Gene_expression (present) of AChE
10) Confidence 0.76 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0
Therefore, the excessive levels of the cholinergic G4 AChE in the brain of cirrhotic subjects may have direct physiological consequences causing a decrease of extracellular ACh levels in the brain.
Gene_expression (levels) of AChE in brain associated with cirrhosis
11) Confidence 0.76 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.21 Pain Relevance 0
To determine if AChE expression is altered in BDL rats, we performed QRT-PCR analysis of the AChE mRNA.
Spec (determine) Gene_expression (expression) of AChE
12) Confidence 0.76 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.06 Pain Relevance 0.14
These results suggest that the cells expressing both acetylcholinesterase activity and enkephalin-like immunoreactivity in culture are EW neurons.
Gene_expression (expressing) of acetylcholinesterase in EW neurons associated with enkephalin
13) Confidence 0.76 Published 1986 Journal Brain Res. Section Abstract Doc Link 2418924 Disease Relevance 0.06 Pain Relevance 0.45
Because TTX did not prevent the increase in AChE expression, it appears that the effects of mechanical stimulation are independent of electrical activity, which further indicates the use of an alternate signaling pathway.
Gene_expression (expression) of AChE associated with tetrodotoxin
14) Confidence 0.76 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.07 Pain Relevance 0.26
Tetrodotoxin (TTX) treatment did not prevent the increase in AChE expression, whereas nifedipine partially blocked it.
Gene_expression (expression) of AChE associated with tetrodotoxin
15) Confidence 0.76 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.08 Pain Relevance 0.27
Together, these results illustrate that, in addition to neural activation and trophic factors, passive mechanical forces modulate expression of AChE in skeletal muscle cells.
Gene_expression (expression) of AChE in neural
16) Confidence 0.76 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.07 Pain Relevance 0.27
Although mechanical stimulation did not affect AChE expression at early time points, it led to a significant increase (42%; P < 0.05) in total AChE activity at 24 h.
Gene_expression (expression) of AChE
17) Confidence 0.76 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.10 Pain Relevance 0.16
We tested the hypothesis that acetylcholinesterase (AChE) expression in skeletal muscle cells is increased by passive mechanical stimulation.
Gene_expression (expression) of AChE in skeletal muscle cells
18) Confidence 0.76 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.08 Pain Relevance 0.11
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
Gene_expression (synthesized) of acetylcholinesterase associated with serotonin
19) Confidence 0.76 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.21
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
Gene_expression (synthesized) of AChE associated with serotonin
20) Confidence 0.76 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.21

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